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November 22, 2009
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bexarotene-oral, Targretin Glossary of Terms

The following are health and medical definitions of terms that appear in the bexarotene-oral, Targretin article.

Birth control : Birth control is the use of any practices, methods, or devices to prevent pregnancy from occurring in a sexually active woman. Also referred to as family planning, pregnancy prevention, fertility control, or contraception; birth control methods are designed either to prevent fertilization of an egg or implantation of a fertilized egg in the uterus.
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Blood: The familiar red fluid in the body that contains white and red blood cells, platelets, proteins, and other elements. The blood is transported throughout the body by the circulatory system. Blood functions in two directions: arterial and venous. Arterial blood is the means by which oxygen and nutrients are transported to tissues while venous blood is the means by which carbon dioxide and metabolic by-products are transported to the lungs and kidneys, respectively, for removal from the body.

Breast : The breast refers to the front of the chest or, more specifically, to the mammary gland. The mammary gland is a milk producing gland. It is composed largely of fat. Within the mammary gland is a complex network of branching ducts. These ducts exit from sac-like structures called lobules, which can produce milk in females. The ducts exit the breast at the nipple.
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Cancer: An abnormal growth of cells which tend to proliferate in an uncontrolled way and, in some cases, to metastasize (spread).
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Cervical: Having to do with any kind of neck including the neck on which the head is perched and the neck of the uterus. The word "cervix" in Latin means "neck". That is why cervical vertebrae and cervical cancer involve quite disparate parts of the anatomy joined only by the meaning of the word "cervix".
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Cervical cap: A soft rubber cup with a round rim designed to fit snugly around the cervix and act as a barrier contraceptive device. A spermicide is applied to the cap before insertion to kill sperm.
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Cholesterol: The most common type of steroid in the body, cholesterol has gotten something of a bad name. However, cholesterol is a critically important molecule.
See the entire definition of Cholesterol

Condition: The term "condition" has a number of biomedical meanings including the following:

  1. An unhealthy state, such as in "this is a progressive condition."
  2. A state of fitness, such as "getting into condition."
  3. Something that is essential to the occurrence of something else; essentially a "precondition."
  4. As a verb: to cause a change in something so that a response that was previously associated with a certain stimulus becomes associated with another stimulus; to condition a person, as in behavioral conditioning.

Condom: Although the word "condom" usually refers to the male condom, there is also a female condom. Both male and female condoms are barrier methods of contraception.
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Cutaneous: Relating to the skin. As, for example, in cutaneous allodynia, a cutaneous papilloma, and cutaneous syndactyly. From the Latin cutis meaning skin.

Diabetes: Refers to diabetes mellitus or, less often, to diabetes insipidus . Diabetes mellitus and diabetes insipidus share the name "diabetes" because they are both conditions characterized by excessive urination (polyuria).
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Diarrhea : A familiar phenomenon with unusually frequent or unusually liquid bowel movements, excessive watery evacuations of fecal material. The opposite of constipation . The word "diarrhea" with its odd spelling is a near steal from the Greek "diarrhoia" meaning "a flowing through." Plato and Aristotle may have had diarrhoia while today we have diarrhea. There are myriad infectious and noninfectious causes of diarrhea.
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Disease: Illness or sickness often characterized by typical patient problems (symptoms) and physical findings (signs). Disruption sequence: The events that occur when a fetus that is developing normally is subjected to a destructive agent such as the rubella (German measles) virus.

Dry skin: Abnormally dry skin . Can be caused by a dry climate, winter weather, deficiency of vitamin A , systemic illness, overexposure to sunlight, or medication . The skin loses moisture. It may crack and peel. Or it may become irritated, inflamed, and itch . Bathing frequently, especially with soaps, can contribute to dry skin.
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Erythromycin: Erythromycin is a common antibiotic for treating bacterial infection. Sold under many brand names, including EES, Erycin and Erythromia.

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Fatigue: A condition characterized by a lessened capacity for work and reduced efficiency of accomplishment, usually accompanied by a feeling of weariness and tiredness. Fatigue can be acute and come on suddenly or chronic and persist.
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Feet: The plural of foot, both an anatomic structure and a unit of measure.
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Fever : Although a fever technically is any body temperature above the normal of 98.6 degrees F. (37 degrees C.), in practice a person is usually not considered to have a significant fever until the temperature is above 100.4 degrees F (38 degrees C.).
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Generic: 1. The chemical name of a drug. 2. A term referring to the chemical makeup of a drug rather than to the advertised brand name under which the drug may be sold. 3.A term referring to any drug marketed under its chemical name without advertising.

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Headache : A pain in the head with the pain being above the eyes or the ears, behind the head (occipital), or in the back of the upper neck. Headache, like chest pain or back ache, has many causes.
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Heart: The muscle that pumps blood received from veins into arteries throughout the body. It is positioned in the chest behind the sternum (breastbone; in front of the trachea, esophagus, and aorta; and above the diaphragm muscle that separates the chest and abdominal cavities. The normal heart is about the size of a closed fist, and weighs about 10.5 ounces. It is cone-shaped, with the point of the cone pointing down to the left. Two-thirds of the heart lies in the left side of the chest with the balance in the right chest.
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Heart disease: Any disorder that affects the heart. Sometimes the term "heart disease" is used narrowly and incorrectly as a synonym for coronary artery disease. Heart disease is synonymous with cardiac disease but not with cardiovascular disease which is any disease of the heart or blood vessels. Among the many types of heart disease, see, for example: Angina; Arrhythmia; Congenital heart disease; Coronary artery disease (CAD); Dilated cardiomyopathy; Heart attack (myocardial infarction); Heart failure; Hypertrophic cardiomyopathy; Mitral regurgitation; Mitral valve prolapse; and Pulmonary stenosis.

Hypothyroid: Deficiency of thyroid hormone which is normally made by the thyroid gland which is located in the front of the neck:

Infant: A child up to 2 years (24 months) of age.
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Infection: The growth of a parasitic organism within the body. (A parasitic organism is one that lives on or in another organism and draws its nourishment therefrom.) A person with an infection has another organism (a "germ") growing within him, drawing its nourishment from the person.
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Kidney: One of a pair of organs located in the right and left side of the abdomen which clear "poisons" from the blood, regulate acid concentration and maintain water balance in the body by excreting urine. The kidneys are part of the urinary tract. The urine then passes through connecting tubes called "ureters" into the bladder. The bladder stores the urine until it is released during urination.


See the entire definition of Kidney

Laboratory: A place for doing tests and research procedures and preparing chemicals, etc. Although "laboratory" looks very like the Latin "laboratorium" (a place to labor, a work place), the word "laboratory" came from the Latin "elaborare" (to work out, as a problem, and with great pains), as evidenced by the Old English spelling "elaboratory" designating "a place where learned effort was applied to the solution of scientific problems."
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Liver: An organ in the upper abdomen that aids in digestion and removes waste products and worn-out cells from the blood. The liver is the largest solid organ in the body. The liver weighs about three and a half pounds (1.6 kilograms). It measures about 8 inches (20 cm) horizontally (across) and 6.5 inches (17 cm) vertically (down) and is 4.5 inches (12 cm) thick.


See the entire definition of Liver

Lymph: An almost colorless fluid that travels through vessels called lymphatics in the lymphatic system and carries cells that help fight infection and disease.

Lymphoma: Tumor of the lymphoid tissue. Diagnosis is by biopsy. Treatment may be chemotherapy, radiation, surgery, or medication, depending on the age of the patient and type of tumor.

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Macrolide: One in a class of antibiotics that includes Biaxin, Clarithromycin , Ery-Tab, and Erythromycin .
See the entire definition of Macrolide

Medical history: 1. In clinical medicine, the patient's past and present which may contain clues bearing on their health past, present, and future. The medical history, being an account of all medical events and problems a person has experienced, including psychiatric illness, is especially helpful when a differential diagnosis is needed.
2. The history of medicine.

MedicAlert: A nonprofit emergency medical information service, known for its MedicAlert jewelry, particularly the bracelet, and its 24-hour emergency response center.
See the entire definition of MedicAlert

Medication: 1. A drug or medicine. 2. The administration of a drug or medicine. (Note that "medication" does not have the dangerous double meaning of "drug.")

Mouth: 1. The upper opening of the digestive tract, beginning with the lips and containing the teeth, gums, and tongue. Foodstuffs are broken down mechanically in the mouth by chewing and saliva is added as a lubricant. Saliva contains amylase, an enzyme that digests starch. 2. Any opening or aperture in the body. The mouth in both senses of the word is also called the os, the Latin word for an opening, or mouth. The o in os is pronounced as in hope. The genitive form of os is oris from which comes the word oral.

Muscle: Muscle is the tissue of the body which primarily functions as a source of power. There are three types of muscle in the body. Muscle which is responsible for moving extremities and external areas of the body is called "skeletal muscle." Heart muscle is called "cardiac muscle." Muscle that is in the walls of arteries and bowel is called "smooth muscle."

Nausea: Nausea is the urge to vomit. It can be brought by many causes including, systemic illnesses, such as influenza, medications, pain, and inner ear disease. When nausea and/or vomiting are persistent, or when they are accompanied by other severe symptoms such as abdominal pain, jaundice, fever, or bleading, a physican should be consulted.

Nose: The external midline projection from the face.
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Pain: An unpleasant sensation that can range from mild, localized discomfort to agony. Pain has both physical and emotional components. The physical part of pain results from nerve stimulation. Pain may be contained to a discrete area, as in an injury, or it can be more diffuse, as in disorders like fibromyalgia . Pain is mediated by specific nerve fibers that carry the pain impulses to the brain where their conscious appreciation may be modified by many factors.
See the entire definition of Pain

Pancreatitis : Inflammation of the pancreas. Of the many diverse causes of pancreatitis , the most common are alcohol and gallstones .


See the entire definition of Pancreatitis

Pharmacist: A professional who fills prescriptions, and in the case of a compounding pharmacist, makes them. Pharmacists are familiar with medication ingredients, interactions, cautions, and hints.
See the entire definition of Pharmacist

Poison: Any substance that can cause severe distress or death if ingested, breathed in, or absorbed through the skin. Many substances that normally cause no problems, including water and most vitamins, can be poisonous if taken in too large of a quantity. Poison treatment depends on the substance: if there are treatment instructions on the substance's container and you are sure it contained no other item, follow those directions immediately. Always contact your nearest Poison Control Center if you are concerned about possible poison ingestion.

Poison Control Center: Special information centers set up to inform Americans about how to respond to potential poisoning. These centers maintain a database of poisons and appropriate emergency treatment. The Poison Control Center in your area should be listed with other community service numbers in the front of your telephone book, and can also be reached immediately through any telephone operator.
See the entire definition of Poison Control Center

Polio: Abbreviation for poliomyelitis, an acute and sometimes devastating disease caused by a virus. Man is the only natural host for polio virus. The virus enters the mouth and multiplies in lymphoid tissues in the throat and intestine. Small numbers of virus enter the blood and go to other sites where the virus multiplies more extensively. Another round of viremia (virus in the bloodstream) leads to invasion of the central nervous system (CNS), the spinal cord and brain, the target sites struck by the virus.
See the entire definition of Polio

Pregnancy: The state of carrying a developing embryo or fetus within the female body. This condition can be indicated by positive results on an over-the-counter urine test, and confirmed through a blood test, ultrasound, detection of fetal heartbeat, or an X-ray. Pregnancy lasts for about nine months, measured from the date of the woman's last menstrual period (LMP). It is conventionally divided into three trimesters, each roughly three months long.
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Pregnant: The state of carrying a developing fetus within the body.
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Prescription: A physician's order for the preparation and administration of a drug or device for a patient. A prescription has several parts. They include the superscription or heading with the symbol "R" or "Rx", which stands for the word recipe (meaning, in Latin, to take); the inscription, which contains the names and quantities of the ingredients; the subscription or directions for compounding the drug; and the signature which is often preceded by the sign "s" standing for signa (Latin for mark), giving the directions to be marked on the container.

Rash : Breaking out (eruption) of the skin. Medically, a rash is referred to as an exanthem.
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Section: 1) In anatomy, a slice of tissue. A biopsy obtained by surgery is usually sectioned (sliced), and these sections are inspected under a microscope. 2) In obstetrics, short for Caesarian section. 3) In surgery, the division of tissue during an operation.

Side effects: Problems that occur when treatment goes beyond the desired effect. Or problems that occur in addition to the desired therapeutic effect.
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Skin: The skin is the body's outer covering. It protects us against heat and light, injury, and infection. It regulates body temperature and stores water, fat, and vitamin D. Weighing about 6 pounds, the skin is the body's largest organ. It is made up of two main layers; the outer epidermis and the inner dermis.


See the entire definition of Skin

Sore: 1. (adjective) A popular term for painful. I have sore fingers from typing dictionary terms. She has a sore throat . 2. (noun) A nondescript term for nearly any lesion of the skin or mucous membranes. He has a number of sores in his mouth.

See the entire definition of Sore

Sore throat : Pain in the throat. Sore throat may be caused by many different causes, including inflammation of the larynx, pharynx, or tonsils.
See the entire definition of Sore throat

Stomach: 1. The sac-shaped digestive organ that is located in the upper abdomen, under the ribs. The upper part of the stomach connects to the esophagus, and the lower part leads into the small intestine.
See the entire definition of Stomach

Sunscreen: A substance that blocks the effect of the sun's harmful rays. Using lotions that contain sunscreens can reduce the risk of skin cancer, including melanoma.

T-cell lymphoma: A disease in which cells in the lymphoid system called T cells (or T lymphocytes) become malignant . T-cell lymphomas account for a minority (about 15%) of non-Hodgkin lymphomas in the US and are more common in Asia.
See the entire definition of T-cell lymphoma

Temperature: The temperature is the specific degree of hotness or coldness of the body. It is usually measured with a thermometer.
See the entire definition of Temperature

Therapy: The treatment of disease .
See the entire definition of Therapy

Throat: The throat is the anterior (front) portion of the neck beginning at the back of the mouth , consisting anatomically of the pharynx and larynx . The throat contains the trachea and a portion of the esophagus .
See the entire definition of Throat

Thyroid: 1. The thyroid gland. Also, pertaining to the thyroid gland. 2. A preparation of the thyroid gland used to treat hypothyroidism. 3. Shaped like a shield. (The thyroid gland was so-named by Thomas Wharton in 1656 because it was shaped like an ancient Greek shield.)

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Urine: Liquid waste. The urine is a clear, transparent fluid. It normally has an amber color. The average amount of urine excreted in 24 hours is from 40 to 60 ounces (about 1,200 cubic centimeters). Chemically, the urine is mainly an aqueous (watery) solution of salt (sodium chloride) and substances called urea and uric acid. Normally, it contains about 960 parts of water to 40 parts of solid matter. Abnormally, it may contain sugar (in diabetes), albumen (a protein) (as in some forms of kidney disease), bile pigments (as in jaundice), or abnormal quantities of one or another of its normal components.

Weight loss: Weight loss is a decrease in body weight resulting from either voluntary (diet, exercise) or involuntary (illness) circumstances. Most instances of weight loss arise due to the loss of body fat, but in cases of extreme or severe weight loss, protein and other substances in the body can also be depleted. Examples of involuntary weight loss include the weight loss associated with cancer, malabsorption (such as from chronic diarrheal illnesses ), and chronic inflammation (such as with rheumatoid arthritis).

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bexarotene-oral, Targretin

Defining cancer

Cancer is a term used for diseases in which abnormal cells divide without control and are able to invade other tissues. Cancer cells can spread to other parts of the body through the blood and lymph systems.

Cancer is not just one disease but many diseases. There are more than 100 different types of cancer. Most cancers are named for the organ or type of cell in which they start -- for example, cancer that begins in the colon is called colon cancer; cancer that begins in basal cells of the skin is called basal cell carcinoma.

Cancer types can be grouped into broader categories. The main categories of cancer include:

  • Carcinoma - cancer that begins in the skin or in tissues that line or cover internal organs.
  • Sarcoma - cancer that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue.
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