betaxolol, Kerlone (Discontinued Brand) (cont.)

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Medical and Pharmacy Editor:

DOSING: Betaxolol usually is taken once daily. The optimal dose varies among patients. The recommended dose range is 5-20 mg daily.

DRUG INTERACTIONS: The blood pressure-lowering effects of betaxolol add to the blood pressure-lowering effects of other drugs. For this reason, combinations of betaxolol and other blood pressure-lowering drugs often are used to treat persons with high blood pressure.

Betaxolol can mask the early warning symptoms of low blood sugar (hypoglycemia) and should be used with caution in patients receiving treatment for diabetes.

When used in combination with diltiazem (Cardizem; Tiazac; Dilacor), verapamil (Calan; Isoptin; Verelan; Covera), amiodarone (Cordarone), or digoxin (Lanoxin), betaxolol or other beta-blockers, can cause complete block of the heart's electrical system causing serious abnormal heart rhythms.

Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Motrin, Advil), naproxen (Naprosyn, Anaprox, Aleve), can reduce the blood pressure lowering effects of beta-blockers such as betaxolol.

PREGNANCY: There is very little information about the effects of betaxolol in pregnant women. Physicians may use betaxolol if its benefits are deemed to outweigh the potential and unknown risks to the fetus.

NURSING MOTHERS: Concentrations of betaxolol in breast milk may be up to three times those in the mother's blood. Therefore, betaxolol is used in nursing mothers only if the benefits outweigh potential risks to the infant.



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