bepridil, Vascor (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
Like other calcium channel blockers, bepridil partially prevents the increase in calcium within the heart's muscle cells that causes the cells to contract. As a result, the muscle cells contract less vigorously. Less vigorous contraction means that the heart works less and needs less oxygen. This effect is useful in treating angina pectoris (heart pain), which occurs when the need of the heart for oxygen to do work exceeds its supply of oxygen. By reducing the need for oxygen, bepridil prevents angina pectoris. Unlike other calcium channel blockers, bepridil does not lower blood pressure and is not used to treat high blood pressure.
Because it can cause abnormal heart rhythms, bepridil generally is reserved for patients who have not responded to other drugs for angina pectoris. Bepridil was approved by the FDA in December 1990.
PRESCRIBED FOR: Bepridil is prescribed for patients with angina pectoris (heart pain) due to coronary artery disease.
SIDE EFFECTS: Bepridil can cause very serious cardiac arrhythmias. The risk is increased in patients with a specific electrocardiographic abnormality called QT prolongation and in patients with low blood concentrations of potassium or magnesium. Bepridil also can cause increased or decreased heart rate and other abnormal rhythms.
Other side effects that can occur among patients taking bepridil include:
Medically Reviewed by a Doctor on 6/17/2015
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