DOSING: Bepridil usually is taken once daily. It can be taken with meals or at bedtime if nausea is a problem.
- Bepridil can reduce the strength with which the heart muscle contracts. Drugs which also have this effect when given together with bepridil could seriously reduce contraction of the heart and possibly precipitate congestive heart failure. Such drugs include quinidine (Quinaglute; Duraquin; Quinidex), procainamide (Procan-SR; Pronestyl), disopyramide (Norpace), flecainide (Tambocor), verapamil (Calan; Isoptin; Covera; Verelan), diltiazem (Cardizem; Tiazac; Dilacor), and all beta-blockers, for example, atenolol (Tenormin).
- Bepridil slows the ability of the heart's muscle to recover electrically and get ready for the next contraction. Other drugs which have the same effect could interact with bepridil, possibly causing serious problems with abnormal heart rhythms and should be used cautiously if at all with bepridil. Such drugs include quinidine (Quinaglute; Duraquin; Quinidex), procainamide (Procan-SR; Pronestyl), disopyramide (Norpace), flecainide (Tambocor), and tricyclic antidepressants, for example, amitriptyline (Elavil, Endep).
- Bepridil may increase levels of digoxin (Lanoxin) in the blood, thereby increasing the risk of digoxin toxicity.
- Diuretics, for example, furosemide (Lasix), bumetanide (Bumex), torsemide Demadex), hydrochlorothiazide (Hydrodiuril), chlorthalidone (Hygroton), metolazone (Zaroxolyn) may cause a reduction in blood potassium concentrations thereby increasing the risk of bepridil-induced abnormal heart rhythms.
PREGNANCY AND BREASTFEEDING SAFETY:
- Bepridil crosses the placenta, and therefore should not be used during pregnancy unless the benefit to the mother outweighs the potential but unknown risk to the fetus.
- Bepridil is secreted into breast milk and therefore should not be used by breastfeeding mothers unless benefit to the mother clearly outweighs the potential but unknown risk to the infant.
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