Benztropine blocks the activity of acetylcholine and can cancel or interfere with the action of drugs that increase gastrointestinal motility (movement of food through the GI tract). Example of such drugs includes:
Umeclidinium (Incruse Ellipta) and tiotropium (Spiriva) may increase the anticholinergic side effects of benztropine. Coadminstration of these agents with benztropine is not recommended.
Benztropine may increase the blood levels of thiazide diuretics. Caution should be used when these agents are used together.
Benztropine may increase the risk of stomach ulcers from using potassium chloride (Klor-Con). Combination treatment with both agents is generally not recommended.
PREGNANCY: Benztropine has not been adequately evaluated in pregnant women. Due to the lack of conclusive safety data, benztropine should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. Benztropine is classified as FDA pregnancy risk category C.
NURSING MOTHERS: It is not known if benztropine is excreted in breast milk. However, antimuscarinic agents have been reported to suppress lactation in animals and decrease prolactin levels in the blood of nursing mothers. Due to the lack of safety data, benztropine should be used cautiously in females who are breastfeeding or avoided.
SIDE EFFECTS: Side effects associated with benztropine treatment include
- rapid heartbeat,
- heat stroke,
- memory problems,
- numbness of fingers,
- psychotic symptoms,
- skin rash,
- dry mouth,
- urinary retention, and
- blurred vision.
REFERENCE: FDA Prescribing Information.
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