benztropine (Cogentin) (cont.)

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Medical and Pharmacy Editor:

ADULT DOSING:

  • For drug induced extrapyramidal symptoms oral, intramuscular or intravenous dosing is available. Treatment is with 1 to 2 mg 2-3 times daily. Treatment should be reevaluated after 12 weeks.
  • Treatment of acute dystonic reactions: The usual recommended dose is 1 to 2 mg intravenous injection to treat acute reactions followed by 1 to 2 mg orally 1 to 2 times daily for up to 7 to 28 days to prevent recurrence.
  • For Parkinsonism, oral, intramuscular or intravenous dosing is available. The usual starting dose is 0.5 to 1 mg daily at bedtime or 2 to 4 divided doses. Dosage may be increased in 0.5 mg increments every 5 to 6 days based on individual response or tolerability. The usual dose range is 0.5 to 6 mg per day. The maximum daily dose is 6 mg.

PEDIATRIC DOSING: For drug induced extrapyramidal symptoms oral, intramuscular or intravenous doses are available.

  • Children = 3 years of age have been treated (off-label) with 0.02 to 0.05 mg/kg/dose 1 to 2 times daily.
  • Adolescents have been treated (off-label) with 1 to 4 mg every 12 to 24 hours.

DRUG INTERACTIONS: Co-adminstration of benztropine with other anticholinergic agents increases the risk of anticholinergic side effects such as:

Commonly used drugs with moderate to significant anticholinergic effects are:

Medically Reviewed by a Doctor on 11/21/2014


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