benztropine (Cogentin)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

What is benztropine mesylate-injection, and how does it work (mechanism of action)?

Benztropine is an oral and injectable synthetic medication. It is structurally similar to atropine (AtroPen) and diphenhydramine (Benadryl). Benztropine has anticholinergic effects. Anticholinergic drugs block the action of acetylcholine, a neurotransmitter (chemical) that nerves use to communicate with other nerves.

In Parkinson's there is an imbalance between levels of dopamine and acetylcholine neurotransmitters. Benztropine helps restore balance by blocking the action of acetylcholine in the central nervous system (brain and spinal cord). Benztropine may also block the uptake and storage of dopamine in the central nervous system (CNS), resulting in the prolongation of the effects of dopamine. Benztropine was approved by the U.S. Food and Administration (FDA) in 1954.

What brand names are available for benztropine mesylate-injection?

Cogentin

Is benztropine mesylate-injection available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for benztropine mesylate-injection?

Yes

What are the side effects of benztropine mesylate-injection?

Side effects associated with benztropine treatment include

Which drugs or supplements interact with benztropine mesylate-injection?

: Co-adminstration of benztropine with other anticholinergic agents increases the risk of anticholinergic side effects such as:

Commonly used drugs with moderate to significant anticholinergic effects are:

Benztropine blocks the activity of acetylcholine and can cancel or interfere with the action of drugs that increase gastrointestinal motility (movement of food through the GI tract). Example of such drugs includes:

Umeclidinium (Incruse Ellipta) and tiotropium (Spiriva) may increase the anticholinergic side effects of benztropine. Coadminstration of these agents with benztropine is not recommended.

Benztropine may increase the blood levels of thiazide diuretics. Caution should be used when these agents are used together.

Benztropine may increase the risk of stomach ulcers from using potassium chloride (Klor-Con). Combination treatment with both agents is generally not recommended.

Medically Reviewed by a Doctor on 5/10/2017

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