benazepril and hydrochlorothiazide, Lotensin HCT (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Hydrochlorothiazide (HCTZ) is a diuretic (water pill) used for treating high blood pressure (hypertension) and accumulation of fluid. It works by blocking salt and fluid reabsorption in the kidneys, causing increased output of salt and water in the urine (diuresis). The mechanism of its action in lowering high blood pressure is not well understood.

The combination of benazepril and HCTZ reduces blood pressure better than either drug alone. Lotensin was approved by the FDA in May 1992.

PRESCRIBED FOR: Lotensin HCT is used for treatment of high blood pressure.

SIDE EFFECTS: Lotensin HCT has side effects of its individual components. The most common side effects are:

A dry, persistent cough has been reported with the use of benazepril and other ACE inhibitors. Coughing resolves after discontinuing the medication.

In rare instances,liver dysfunction and skin yellowing (jaundice) have been reported with ACE inhibitors. Benazepril should not be taken by people with a known allergy to ACE inhibitors. Swelling of the facial tissues and even the upper airways has been reported with ACE inhibitors on very rare occasions, and can lead to serious breathing difficulties.

Benazepril may reduce kidney function in some patients and should not be used by patients who have bilateral renal artery stenosis (narrowing of both arteries supplying the kidneys). Rare cases of rhabdomyolysis (muscle breakdown), reduced number of platelets, and pancreatitis have been reported. Hydrochlorothiazide may increase blood glucose levels.

Medically Reviewed by a Doctor on 7/21/2015


Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Pill Finder Tool

Need help identifying pills and medications?
Use the pill identifier tool on RxList.


Back to Medications Index