benazepril and hydrochlorothiazide, Lotensin HCT

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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Hydrochlorothiazide (HCTZ) is a diuretic (water pill) used for treating high blood pressure (hypertension) and accumulation of fluid. It works by blocking salt and fluid reabsorption in the kidneys, causing increased output of salt and water in the urine (diuresis). The mechanism of its action in lowering high blood pressure is not well understood.

The combination of benazepril and HCTZ reduces blood pressure better than either drug alone. Lotensin was approved by the FDA in May 1992.

PRESCRIBED FOR: Lotensin HCT is used for treatment of high blood pressure.

SIDE EFFECTS: Lotensin HCT has side effects of its individual components. The most common side effects are:

A dry, persistent cough has been reported with the use of benazepril and other ACE inhibitors. Coughing resolves after discontinuing the medication.

In rare instances,liver dysfunction and skin yellowing (jaundice) have been reported with ACE inhibitors. Benazepril should not be taken by people with a known allergy to ACE inhibitors. Swelling of the facial tissues and even the upper airways has been reported with ACE inhibitors on very rare occasions, and can lead to serious breathing difficulties.

Medically Reviewed by a Doctor on 7/21/2015

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