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- What is benazepril and hydrochlorothiazide, and how does it work (mechanism of action)?
- What brand names are available for benazepril and hydrochlorothiazide?
- Is benazepril and hydrochlorothiazide available as a generic drug?
- Do I need a prescription for benazepril and hydrochlorothiazide?
- What are the side effects of benazepril and hydrochlorothiazide?
- What is the dosage for benazepril and hydrochlorothiazide?
- Which drugs or supplements interact with benazepril and hydrochlorothiazide?
- Is benazepril and hydrochlorothiazide safe to take if I'm pregnant or breastfeeding?
- What else should I know about benazepril and hydrochlorothiazide?
What is benazepril and hydrochlorothiazide, and how does it work (mechanism of action)?
Lotensin HCT is a combination of two drugs, benazepril and hydrochlorothiazide. Benazepril is an angiotensin converting enzyme (ACE) inhibitor that is used for treating high blood pressure. Other ACE inhibitors include enalapril (Vasotec), quinapril (Accupril), captopril (Capoten), fosinopril (Monopril), ramipril (Altace), moexipril (Univasc) and trandolapril (Mavik). ACE is an enzyme in the body which is important for the formation of angiotensin II. Angiotensin II causes constriction of arteries in the body, thereby elevating blood pressure. ACE inhibitors (for example, benazepril) lower blood pressure by inhibiting the formation of angiotensin II, thus relaxing the arteries. Relaxing the arteries not only lowers blood pressure, but the lower blood pressure also reduces the heart's work and improves the output of blood from the heart in patients with heart failure.
Hydrochlorothiazide (HCTZ) is a diuretic (water pill) used for treating high blood pressure (hypertension) and accumulation of fluid. It works by blocking salt and fluid reabsorption in the kidneys, causing increased output of salt and water in the urine (diuresis). The mechanism of its action in lowering high blood pressure is not well understood.
The combination of benazepril and HCTZ reduces blood pressure better than either drug alone. Lotensin was approved by the FDA in May 1992.
What brand names are available for benazepril and hydrochlorothiazide?
Is benazepril and hydrochlorothiazide available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for benazepril and hydrochlorothiazide?
What are the side effects of benazepril and hydrochlorothiazide?
Lotensin HCT has side effects of its individual components. The most common side effects are:
- low blood pressure,
- muscle pain,
- stomach upset,
- sexual dysfunction, and
- decreased or increased potassium blood levels.
In rare instances,liver dysfunction and skin yellowing (jaundice) have been reported with ACE inhibitors. Benazepril should not be taken by people with a known allergy to ACE inhibitors. Swelling of the facial tissues and even the upper airways has been reported with ACE inhibitors on very rare occasions, and can lead to serious breathing difficulties.
Benazepril may reduce kidney function in some patients and should not be used by patients who have bilateral renal artery stenosis (narrowing of both arteries supplying the kidneys). Rare cases of rhabdomyolysis (muscle breakdown), reduced number of platelets, and pancreatitis have been reported. Hydrochlorothiazide may increase blood glucose levels.
Quick GuideHow to Lower Blood Pressure: Exercise Tips
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