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February 10, 2012

becaplermin, Regranex Glossary of Terms

The following are health and medical definitions of terms that appear in the becaplermin, Regranex article.

Amputation: Removal of part or all of a body part enclosed by skin. For example, removal of part of a finger or an entire finger would be termed an amputation. Removal of an appendix, on the other hand, would not be termed amputation. A person who has undergone an amputation is called an amputee.
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Ankle: The ankle joint is complex. It is made up of two joints: the true ankle joint and the subtalar joint:
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Bacterial: Of or pertaining to bacteria. For example, a bacterial lung infection.

Breast milk: Milk from the breast. Human milk contains a balance of nutrients that closely matches infant requirements for brain development, growth and a healthy immune system. Human milk also contains immunologic agents and other compounds that act against viruses, bacteria, and parasites. Since an infant's immune system is not fully developed until age 2, human milk provides a distinct advantage over formula.
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Debridement: The act of debriding (removing dead, contaminated or adherent tissue or foreign material). Debridement encompasses enzymatic debridement (as with proteolytic enzymes), mechanical nonselective debridement (as in a whirlpool), and sharp debridement (by surgery). See: Debride.

DNA: Deoxyribonucleic acid. One of two types of molecules that encode genetic information. (The other is RNA. In humans DNA is the genetic material; RNA is transcribed from it. In some other organisms, RNA is the genetic material and, in reverse fashion, the DNA is transcribed from it.)
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Expiration date: The date for a drug estimated for its shelf life with proper storage in sealed containers away from harmful and variable factors like heat and humidity.
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FDA: The Food and Drug Administration, an agency within the U.S. Public Health Service, which is a part of the Department of Health and Human Services.
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Generic: 1. The chemical name of a drug. 2. A term referring to the chemical makeup of a drug rather than to the advertised brand name under which the drug may be sold. 3.A term referring to any drug marketed under its chemical name without advertising.

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Infant: A child up to 2 years (24 months) of age.
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Infection: The growth of a parasitic organism within the body. (A parasitic organism is one that lives on or in another organism and draws its nourishment therefrom.) A person with an infection has another organism (a "germ") growing within him, drawing its nourishment from the person.
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Inflammation: A basic way in which the body reacts to infection, irritation or other injury, the key feature being redness, warmth, swelling and pain. Inflammation is now recognized as a type of nonspecific immune response.
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Injury: Harm or hurt. The term "injury" may be applied in medicine to damage inflicted upon oneself as in a hamstring injury or by an external agent on as in a cold injury. The injury may be accidental or deliberate, as with a needlestick injury. The term "injury" may be synonymous (depending on the context) with a wound or with trauma.

Leg: In popular usage, the leg extends from the top of the thigh down to the foot. However, in medical terminology, the leg refers to the portion of the lower extremity from the knee to the ankle.
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Nursing: 1) Profession concerned with the provision of services essential to the maintenance and restoration of health by attending the needs of sick persons. 2) Feeding a infant at the breast.

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Osteomyelitis: Inflammation of the bone due to infection, for example by the bacteria salmonella or staphylococcus. Osteomyelitis is sometimes a complication of surgery or injury, although infection can also reach bone tissue through the bloodstream. Both the bone and the bone marrow may be infected. Symptoms include deep pain and muscle spasms in the area of inflammation, and fever. Treatment is by bed rest, antibiotics (usually injected locally), and sometimes surgery to remove dead bone tissue.

Placebo: A "sugar pill" or any dummy medication or treatment.
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Pregnancy: The state of carrying a developing embryo or fetus within the female body. This condition can be indicated by positive results on an over-the-counter urine test, and confirmed through a blood test, ultrasound, detection of fetal heartbeat, or an X-ray. Pregnancy lasts for about nine months, measured from the date of the woman's last menstrual period (LMP). It is conventionally divided into three trimesters, each roughly three months long.
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Pregnant: The state of carrying a developing fetus within the body.
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Prescription: A physician's order for the preparation and administration of a drug or device for a patient. A prescription has several parts. They include the superscription or heading with the symbol "R" or "Rx", which stands for the word recipe (meaning, in Latin, to take); the inscription, which contains the names and quantities of the ingredients; the subscription or directions for compounding the drug; and the signature which is often preceded by the sign "s" standing for signa (Latin for mark), giving the directions to be marked on the container.

Proteins: Large molecules composed of one or more chains of amino acids in a specific order determined by the base sequence of nucleotides in the DNA coding for the protein.
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Rash: Breaking out (eruption) of the skin. Medically, a rash is referred to as an exanthem.

Recombinant: A person with a new combination of genes, a combination of genes not present in either parent, due to parental recombination of those genes.

Tongue: The tongue is a strong muscle anchored to the floor of the mouth. It is covered by the lingual membrane which has special areas to detect tastes.
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Tubes: The "tubes" are medically known as the Fallopian tubes. There are two Fallopian tubes, one on each side, which transport the egg from the ovary to the uterus (the womb). The Fallopian tubes have small hair-like projections called cilia on the cells of the lining.
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Ulcer: An area of tissue erosion, for example, of the skin or lining of the gastrointestinal (GI) tract. Due to the erosion, an ulcer is concave. It is always depressed below the level of the surrounding tissue.
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Diabetes Facts

  • Diabetes is a chronic condition associated with abnormally high levels of sugar (glucose) in the blood.
  • Insulin produced by the pancreas lowers blood glucose.
  • Absence or insufficient production of insulin causes diabetes.
  • The two types of diabetes are referred to as type 1 (insulin dependent) and type 2 (non-insulin dependent).
  • Symptoms of diabetes include increased urine output, thirst and hunger as well as fatigue.
  • Diabetes is diagnosed by blood sugar (glucose) testing.
  • The major complications of diabetes are both acute and chronic.

    • Acutely: dangerously elevated blood sugar, abnormally low blood sugar due to diabetes medications may occur.
    • Chronically: disease of the blood vessels (both small and large) which can damage the eye, kidneys, nerves, and heart may occur

  • Diabetes treatment depends...

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