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The Cleveland Clinic

Multiple Sclerosis: Intrathecal Baclofen Pump Therapy

Baclofen is a medication commonly used to decrease spasticity related to multiple sclerosis, spinal cord injuries, or other neurological diseases. Spasticity is a muscle problem characterized by tight or stiff muscles that may interfere with voluntary muscle movements.

How Does Baclofen Work?

Normally muscles receive electrical signals via nerves to contract and relax. Spasticity is caused by an imbalance of electrical signals coming from the spinal cord through the nerves to the muscle. This imbalance causes the muscle to become hyperactive, resulting in involuntary spasms. Baclofen works by restoring the normal balance and reducing muscle hyperactivity. In this way, it allows for more normal muscle movements.

What Are the Side Effects of Baclofen Therapy?

Side effects may include:

  • dizziness
  • Drowsiness
  • Headaches
  • Nausea
  • Weakness


Next: What is intrathecal Baclofen? »

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