baclofen, Gablofen, Lioresal (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Abrupt discontinuation of oral baclofen may cause seizures and hallucinations. Abrupt discontinuation of intrathecal baclofen may result in:

  • high fever,
  • rebound spasticity,
  • muscle rigidity, and
  • rhabdomyolysis (muscle breakdown) that can progress to failure of several organs, including the kidney, and even death.



PREPARATIONS: Tablets: 10 and 20 mg. Intrathecal: 0.05 mg/ml, 0.5 mg/ml, 1 MG/ML, 2 mg/ml

STORAGE: Baclofen should be stored between 15 C (59 F) and 30 C (86 F).

DOSING: The usual starting dose of oral baclofen for treating spasticity in adults is 5 mg given three times daily. Based on the response, the dose can be increased by 5 mg every three days to a maximum of 80 mg/day in divided doses.

DRUG INTERACTIONS: Use of baclofen with other drugs that also depress the function of nerves may lead to additional reduction in brain function.

In addition to the risk of depressing brain function, the use of baclofen and tricyclic antidepressants (for example, amitriptyline [Elavil, Endep], doxepin [Sinequan, Adapin]) together may cause muscle weakness.

Use of baclofen and monoamine oxidase inhibitors (for example, phenelzine [Nardil], tranylcypromine or [Parnate]) can result in greater depression of brain function as well as low blood pressure.

Medically Reviewed by a Doctor on 6/8/2015

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