baclofen, Lioresal, Kemstro (discontinued)

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GENERIC NAME: baclofen

BRAND NAME: Lioresal, Kemstro (discontinued)

DRUG CLASS AND MECHANISM: Baclofen is an oral and injectable medication that relaxes skeletal muscles, the muscles that move the skeleton (and also called striated muscle). Chemically, baclofen is related to gamma-aminobutyric acid (GABA), a naturally-occurring neurotransmitter in the brain. Neurotransmitters are chemicals that nerves use to communicate with one another. GABA released by some nerves causes the activity of other nerves to decrease. It is believed that baclofen, acting like GABA, blocks the activity of nerves within the part of the brain that controls the contraction and relaxation of skeletal muscle. Baclofen was approved by the FDA in November 1977.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Tablets: 10 and 20 mg. Intrathecal: 0.05 mg/ml, 0.5 mg/ml, 2 mg/ml

STORAGE: Baclofen should be stored between 15 C (59 F) and 30 C (86 F).

PRESCRIBED FOR: Baclofen is used for treating spasm of skeletal muscles, muscle clonus, rigidity, and pain caused by disorders such as multiple sclerosis. It is also injected into the spinal cord (intrathecal) for management of severe spasticity.

DOSING: The usual starting dose of oral baclofen for adults is 5 mg given three times daily. Based on the response, the dose can be increased by 15 mg every three days to a maximum of 80 mg/day in divided doses.




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