azelastine hydrochloride and fluticasone propionate (Dymista)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

GENERIC NAME: azelastine hydrochloride and fluticasone propionate

BRAND NAME: Dymista

DRUG CLASS AND MECHANISM: Dymista is a prescription nasal spray used to treat symptoms of seasonal allergic rhinitis (inflammation of the lining of the nose) such as runny nose, stuffy nose, itching, and sneezing. Dymista contains two medicines, azelastine hydrochloride and fluticasone propionate, which are also available individually as nasal sprays. In Dymista, azelastine hydrochloride an antihistamine, and fluticasone propionate, a corticosteroid work in different yet complementary ways.

Azelastine hydrochloride blocks the release and actions of histamine, a chemical responsible for causing many of the symptoms of allergy. Fluticasone propionate is a corticosteroid that reduces inflammation and the body's immune response. When used together, azelastine hydrochloride and fluticasone propionate provide better relief of symptoms than either medicine alone. In clinical trials, Dymista was superior to azelastine nasal spray, fluticasone nasal spray, and placebo in providing symptom relief. Dymista was approved by the FDA in May, 2012.

PRESCRIBED FOR: Dymista is a prescription nasal spray used to treat symptoms of seasonal allergic rhinitis such as runny nose, stuffy nose, itching, and sneezing in patients 12 years of age and older who do not respond adequately to either azelastine hydrochloride or fluticasone propionate alone.

SIDE EFFECTS: The most common side effects of Dymista are changes in taste, nosebleeds, and headache.

Dymista may cause some more serious side effects including:

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