• Pharmacy Author:
    Annette (Gbemudu) Ogbru, PharmD, MBA

    Dr. Gbemudu received her B.S. in Biochemistry from Nova Southeastern University, her PharmD degree from University of Maryland, and MBA degree from University of Baltimore. She completed a one year post-doctoral fellowship with Rutgers University and Bristol Myers Squibb.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

  • Pharmacy Author: Omudhome Ogbru, PharmD
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

What is the dosage for azathioprine?

The initial dose for preventing organ rejection is 3 to 5 mg/kg (oral or IV) daily, starting at the time of transplantation or in some cases 1 to 3 days before transplantation. The initial off-label dose for treating rheumatoid arthritis is 1.0 mg/kg (50 to 100 mg, oral or IV) as a single dose or twice daily. Doses may be increased by 0.5 mg/kg daily up to a maximum dose of 2.5 mg/kg per day. Dosing for other off-label use may vary according to what disease is being treated; in general, off-label use should be done by an experienced medical specialist. Azathioprine should be taken with food.

Which drugs or supplements interact with azathioprine?

Allopurinol (Zyloprim) that is used for treating increased blood levels of uric acid and preventing gout increases azathioprine levels in the blood which may increase the risk of side effects from azathioprine. Therefore, it is important to reduce the dose of azathioprine by approximately 1/3 to 1/4 in patients taking allopurinol. The use of angiotensin-converting enzyme (ACE) inhibitors to control high blood pressure in patients taking azathioprine has been reported to induce anemia (low levels of red blood cells) and severe leukopenia (low levels of white blood cells). Azathioprine reduces blood levels of the blood thinner, warfarin (Coumadin), and thus may reduce the blood thinning effect of warfarin.

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