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azathioprine - injection, Imuran

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GENERIC NAME: AZATHIOPRINE - INJECTION (ay-za-THYE-oh-preen)

BRAND NAME(S): Imuran

Warning | Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage

WARNING: Long-term use of azathioprine may increase your risk of developing certain types of cancer (e.g., skin cancer, lymphoma). You must be closely monitored by your doctor during treatment and regularly afterwards if your doctor stops treatment with this medication. Azathioprine may also cause serious (rarely fatal) blood disorders (decreased bone marrow function leading to anemia, low number of white blood cells and platelets). It can lower your body's ability to fight an infection. The risk of these side effects is higher in patients receiving this medication to prevent kidney transplant rejection than in patients treated for rheumatoid arthritis. To reduce the risk of side effects, use this medication at the lowest effective dose. Keep all medical and laboratory appointments.

Tell your doctor immediately if you develop any of the following signs: unusual skin changes, change in the appearance/size of moles, unusual growths/lumps, swollen glands, swollen or painful abdomen, unexplained weight loss, night sweats, unexplained itching, signs of infection (e.g., fever, persistent sore throat), easy bruising/bleeding, or unusual tiredness.

USES: Azathioprine is used with other medications to prevent rejection of a kidney transplant. It works by weakening your body's defense system (immune system) to help your body accept the new kidney as if it were your own. This medication belongs to a class of drugs known as immunosuppressants.Azathioprine is also used to treat patients with severe rheumatoid arthritis who have not responded to other medications (e.g., nonsteroidal anti-inflammatory drugs/NSAIDs such as ibuprofen). Rheumatoid arthritis is thought to be caused by the immune system attacking the joints. Early treatment of rheumatoid arthritis with more aggressive therapy such as azathioprine helps to reduce further joint damage and to keep joints working better.This medication is given by injection until you are able to take azathioprine by mouth.Talk to the doctor about the risks and benefits of azathioprine, especially when used in children and young adults.OTHER This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.This medication may also be used to prevent rejection of other transplanted organs, to treat a certain type of bowel condition (Crohn's disease) that is not responsive to usual treatment, and to treat other immune system problems (autoimmune diseases) as determined by your doctor.

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