avanafil, Stendra (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
GENERIC AVAILABLE: No.
PREPARATIONS: Tablets: 50, 100 and 200 mg.
STORAGE: Avanafil should be stored at room temperature between 20 C and 25 C (68 F and 77 F).
DOSING: For most individuals, the recommended starting dose of avanafil is 100 mg per day taken about 30 minutes before sexual activity. Depending on the adequacy of the response or side effects, the dose may be increased to 200 mg or decreased to 50 mg a day. Individuals who are taking medications that moderately increase the blood levels of avanafil should not exceed a total dose of 50 mg in 24 hours (See drug interactions).
DRUG INTERACTIONS: The breakdown and elimination of avanafil from the body may be decreased by several drugs, leading to increased blood levels of avanafil and possible toxicity. Ketoconazole (Nizoral), itraconazole (Sporanox), indinavir (Crixivan) and ritonavir (Norvir), atazanavir (Reyataz), clarithromycin (Biaxin), nelfinavir (Viracept), saquinavir (Invirase), telithromycin (Ketek) profoundly increase blood levels of avanafil and should not be combined with avanafil.
The dose of avanafil should not exceed 50 mg daily when combined with erythromycin, amprenavir (Agenerase), aprepitant (Emend), diltiazem (Cardizem), fluconazole (Diflucan), fosamprenavir (Lexiva), and verapamil (Calan) because these drug moderately increase blood levels of avanafil.
Medically Reviewed by a Doctor on 2/26/2015
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