avanafil, Stendra

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

What is avanafil (Stendra), and how does it work (mechanism of action)?

Avanafil is an oral drug that is used for treating impotence (the inability to attain or maintain a penile erection), also known as erectile dysfunction (ED). It is in a class of drugs called phosphodiesterase inhibitors that also includes tadalafil (Cialis), sildenafil (Viagra) and vardenafil (Levitra). Erection of the penis is caused by the filling of the penis with blood. Filling occurs because the blood vessels that bring blood to the penis increase in size and deliver more blood to the penis, and, at the same time, the blood vessels that take blood away from the penis decrease in size and remove less blood from the penis. Sexual stimulation that leads to an erection causes the production and release of nitric oxide in the penis. The nitric oxide causes an enzyme, guanylate cyclase, to produce cyclic guanosine monophosphate (cGMP). It is cGMP that is primarily responsible for increasing and decreasing the size of blood vessels carrying blood to and from the penis, respectively, and causing an erection. When the cGMP is destroyed by another enzyme, phosphodiesterase-5, the blood vessels return to their normal size, blood leaves the penis, and the erection ends. Avanafil prevents phosphodiesterase-5 from destroying cGMP so that cGMP stays around longer. The persistence of cGMP leads to a more prolonged engorgement of the penis with blood. Avanafil was approved by the FDA in April 2012.

What brand names are available for avanafil (Stendra)?

Stendra

Is avanafil (Stendra) available as a generic drug?

GENERIC AVAILABLE: No.

Do I need a prescription for avanafil (Stendra)?

Yes.

What are the side effects of avanafil (Stendra)?

The most common side effects of avanafil are:

Avanafil also may cause low blood pressure, blurred vision and changes in color vision, and abnormal ejaculation. Avanafil may cause prolonged erections or priapism (painful erections lasting more than 6 hours). Patients should seek immediate medical help if they experience an erection lasting more than 4 hours.

Use of avanafil, especially in patients with pre-existing heart disease, may cause

Rare cases of sudden loss of hearing have been reported with phosphodiesterase inhibitors such as avanafil, sometimes associated with ringing in the ears and dizziness. If changes in hearing occur, patients should stop their avanafil and seek immediate medical attention. Phosphodiesterase-5 inhibitors have been associated rarely with non-arteritic anterior ischemic optic neuropathy (NAION), a condition which causes decreased vision and may lead to blindness.

Quick GuideErectile Dysfunction (ED) Causes and Treatment

Erectile Dysfunction (ED) Causes and Treatment
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