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- What is aurothiomalate, and how does it work (mechanism of action)?
- What brand names are available for aurothiomalate?
- Is aurothiomalate available as a generic drug?
- Do I need a prescription for aurothiomalate?
- What are the side effects of aurothiomalate?
- What is the dosage for aurothiomalate?
- Which drugs or supplements interact with aurothiomalate?
- Is aurothiomalate safe to take if I'm pregnant or breastfeeding?
- What else should I know about aurothiomalate?
What is aurothiomalate, and how does it work (mechanism of action)?
Gold sodium thiomalate is a gold-containing chemical (salt) used in treating rheumatoid arthritis. Other gold salts available include injectable aurothioglucose (Solganal) and oral auranofin (Ridaura). It is not well understood exactly how gold salts work. In patients with inflammatory arthritis, such as adult and juvenile rheumatoid arthritis, gold salts decrease the inflammation of the joint lining and also prevent the inflammation from destroying the bone and cartilage surrounding the joint. Because they prevent destruction of joints (in contrast to antiinflammatory drugs that just treat symptoms and signs of arthritis but do not prevent the destruction) gold thiomalate is known as a disease-modifying antirheumatic drug (DMARD). Gold salts also may be referred to as second-line drugs because they are often considered when the arthritis persists in spite of the use of antiinflammatory drugs (NSAIDs and corticosteroids) which are not DMARDs. The term, second line, may be misleading, however, since anti-inflammatory drugs and DMARDs in general should be used together because of their different mechanisms of action and additive effects.
What brand names are available for aurothiomalate?
Is aurothiomalate available as a generic drug?
GENERIC AVAILABLE: No
Do I need a prescription for aurothiomalate?
What are the side effects of aurothiomalate?
The most common adverse reactions to gold sodium thiomalate are:
- dermatitis (skin inflammation),
- pruritus (itching),
- stomatitis (inflammation affecting the structures in the mouth such as cheeks, gums, tongue, lips, throat), and
- serious kidney and bone marrow problems.
Because gold sodium thiomalate can cause bone marrow problems, all patients require regular monitoring with blood and urine tests.
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