aurothioglucose (cont.)

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Medical and Pharmacy Editor:

DOSING: The usual initial adult dose is 10 mg followed by 25 mg for the second and third doses, then 50 mg weekly until 0.8 to1 g has been administered. The usual dose for children is one-fourth of the adult dose of aurothioglucose, exceeding 25 mg per dose.

DRUG INTERACTIONS: The concurrent use of penicillamine (Cuprimine, Depen) and aurothioglucose should be avoided as the combination decreases the levels and efficacy of both drugs due to chelation (binding) of the gold salt to the penicillamine.

PREGNANCY: There are no adequate and well-controlled studies in pregnant women. Aurothioglucose should be used during pregnancy only if the potential benefit to the mother justifies the potential risk to the fetus.

NURSING MOTHERS: Aurothioglucose has been found in the breast milk of women. Due to the potential for serious adverse reactions in nursing infants, decisions should be made whether to discontinue nursing or to discontinue the drug.

SIDE EFFECTS: The most common adverse reactions to aurothioglucose is dermatitis (skin inflammation), pruritus (itching), stomatitis (inflammation affecting the structures in the mouth such as cheeks, gums, tongue, lips, throat). Aurothoglucose can also suppress the bone marrow leading to abnormally low blood counts, including leukopenia, thrombocytopenia, and anemia. It can also cause kidney damage manifest by protein loss in the urine.

REFERENCE: FDA Prescribing Information


Medically Reviewed by a Doctor on 10/8/2014


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