GENERIC NAME: auranofin
BRAND NAME: Ridaura
DRUG CLASS AND MECHANISM: Auranofin is an oral, gold-containing chemical (salt) used for treating rheumatoid arthritis. Other gold salts available are injectable and include aurothioglucose (Solganal) and gold sodium thiomalate (Myochrysine). It is not well understood exactly how gold salts work. In patients with inflammatory arthritis, such as adult and juvenile rheumatoid arthritis, gold salts decrease the inflammation of the lining of the joint. They prevent the inflammation from destroying the bone and cartilage surrounding the joint and deformities of the joints. Because of its ability to prevent or slow deformities of the joints, auranofin is considered a disease modifying anti-rheumatic drug (DMARD). Gold salts also are called second-line drugs because they often are considered when arthritis persists in spite of the use of antiinflammatory drugs (NSAIDs and corticosteroids). The term second-line is misleading since anti-inflammatory drugs and DMARDs have different mechanisms of action and in general are used together for their additive effects. DMARDs may take weeks to months to become effective. Auranofin was FDA approved in May 1985.
PRESCRIBED FOR: Auranofin is used in the treatment of active, progressive or destructive forms of inflammatory arthritis, such as rheumatoid arthritis. Off label uses include Felty's Syndrome (a rare disorder that includes rheumatoid arthritis, a swollen spleen, and decreased white blood cell count), psoriatic arthritis and juvenile rheumatoid arthritis.
SIDE EFFECTS: The most common side effects of auranofin are:
Quick GuideRheumatoid Arthritis (RA) Pictures Slideshow
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