attapulgite, Rheaban; Kaopectate Advanced Formula; Parepectolin; Diasorb; Diatrol; Donnagel

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

woman with abdominal pain

What is attapulgite, and how does it work (mechanism of action)?

Attapulgite is an oral, nonabsorbed medication that is used in the management of diarrhea. It works by adsorbing (binding) large numbers of bacteria and toxins and reducing the loss of water. Attapulgite reduces the number of bowel movements, improves the consistency of loose or watery stools, and relieves the gastrointestinal cramping that often is associated with diarrhea.

Is attapulgite available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for attapulgite?

No

What are the side effects of attapulgite?

Constipation is the main side effect of attapulgite. It can also cause:

Quick GuideDigestive Disorders: Common Misconceptions

Digestive Disorders: Common Misconceptions

What is the dosage for attapulgite?

Attapulgite is taken after each loose bowel movement.

  • Adults and adolescents over the age of 12 years may take 1.2 to 1.5 grams per dose, up to 8.4 grams per day.
  • Children 6 to 12 years of age may take 600 to 750 mg after each loose bowel movement and up to 4.5 grams per day.
  • Children 3 to 6 years of age may take 300 mg after each loose bowel movement up to a total of 2.1 grams (7 doses) per day.

Which drugs or supplements interact with attapulgite?

Attapulgite can decrease the absorption of benztropine (Cogentin), trihexyphenidyl (Artane), loxapine (Loxitane) and dicyclomine (Bentyl) if taken at the same time. These medications should be taken at least 2 hours earlier or later than attapulgite. Attapulgite and other antidiarrheals can worsen constipation caused by opiate pain relievers such as oxycodone (Percocet), hydrocodone (Vicodin), propoxyphene (Darvon), morphine, and codeine.

Is attapulgite safe to take if I'm pregnant or breastfeeding?

Attapulgite is safe during pregnancy.

Attapulgite is safe to use in nursing mothers.

What else should I know about attapulgite?

What preparations of attapulgite are available?

Suspension: 600 mg/15ml or 750 mg/ml

How should I keep attapulgite stored?

Preparations should be stored at room temperature, 15 C - 30 C (59 F - 86 F).

Reference: FDA Prescribing Information

Last Editorial Review: 5/27/2015

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Reviewed on 5/27/2015
References
Reference: FDA Prescribing Information

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