attapulgite, Rheaban; Kaopectate Advanced Formula; Parepectolin; Diasorb; Diatrol; Donnagel

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Medical and Pharmacy Editor:

GENERIC NAME: attapulgite

BRAND NAME: Rheaban, Kaopectate Advanced Formula, Parepectolin, Diasorb, Diatrol, Donnagel

DRUG CLASS AND MECHANISM: Attapulgite is an oral, nonabsorbed medication that is used in the management of diarrhea. It works by adsorbing (binding) large numbers of bacteria and toxins and reducing the loss of water. Attapulgite reduces the number of bowel movements, improves the consistency of loose or watery stools, and relieves the gastrointestinal cramping that often is associated with diarrhea.

GENERIC AVAILABLE: Yes

PRESCRIPTION: No

PREPARATIONS: Suspension: 600 mg/15ml or 750 mg/ml

STORAGE: Preparations should be stored at room temperature, 15-30 C (59-86 F).

PRESCRIBED FOR: Attapulgite is used for the short-term treatment of diarrhea.

DOSING: Attapulgite is taken after each loose bowel movement.

  • Adults and adolescents over the age of 12 years may take 1.2 to 1.5 grams per dose, up to 8.4 grams per day.
  • Children 6 to 12 years of age may take 600 to 750 mg after each loose bowel movement and up to 4.5 grams per day.
  • Children 3 to 6 years of age may take 300 mg after each loose bowel movement up to a total of 2.1 grams (7 doses) per day.

DRUG INTERACTIONS: Attapulgite can decrease the absorption of benztropine (Cogentin), trihexyphenidyl (Artane), loxapine (Loxitane) and dicyclomine (Bentyl) if taken at the same time. These medications should be taken at least 2 hours earlier or later than attapulgite. Attapulgite and other antidiarrheals can worsen constipation caused by opiate pain relievers such as oxycodone (Percocet), hydrocodone (Vicodin), propoxyphene (Darvon), morphine, and codeine.

PREGNANCY: Attapulgite is safe during pregnancy.

NURSING MOTHERS: Attapulgite is safe to use in nursing mothers.

SIDE EFFECTS: Constipation is the main side effect of attapulgite. It can also cause bloating, flatulence, stomach upset, and nausea.

Reference: FDA Prescribing Information


Last Editorial Review: 7/20/2012




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