atropine ophthalmic

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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What is atropine sulfate ointment-ophthalmic, and how does it work (mechanism of action)?

Atropine occurs naturally and is extracted from belladonna alkaloids contained in plants. Atropine blocks the action of acetylcholine, a neurotransmitter that causes the contraction of two types of muscle, smooth and cardiac muscles. It also has other neurological effects. Ophthalmic atropine is used during eye examinations to dilate the pupil. Atropine is also used to weaken the contraction of the muscles within the eyes, both the muscles that operate the iris and the lens. Paralysis of the lens, called cycloplegia, results in the loss of the ability to focus vision. Paralysis of the iris (mydriasis) prevents the iris from adjusting to the brightness of incoming light and affects the ability to see clearly. In clinical studies, use of a single topical administration of atropine 1% ophthalmic solution (eye drops) resulted in maximal mydriasis (pupil dilation or widening) in approximately 40 minutes and maximal cycloplegia in approximately 60 to 90 minutes. In most cases, full recovery occurred in approximately one week but can take a couple of weeks. The FDA approved atropine in 1938.

What brand names are available for atropine sulfate ointment-ophthalmic?

N/A

Is atropine sulfate ointment-ophthalmic available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for atropine sulfate ointment-ophthalmic?

Yes

What are the side effects of atropine sulfate ointment-ophthalmic?

The most common side effects reported include

What is the dosage for atropine sulfate ointment-ophthalmic?

  • For inducing mydriasis (pupil dilation) or cycloplegia in adults: Instill 1-2 drops of 1% ophthalmic solution in eye 1 hour before procedure.
  • For the treatment of inflammatory conditions of the eye (iritis or uveitis) in adults: Instill 1-2 drops of 1% solution in eye up to 4 times per day.

Which drugs or supplements interact with atropine sulfate ointment-ophthalmic?

:

Use of atropine with monoamine oxidase inhibitors (MAOI) is not recommended due to the risk of causing severely elevated blood pressure (hypertensive crisis). Examples of MAO inhibitors include

Patients should ask their doctor or pharmacist before using atropine eye products if they are taking certain drugs such as

Is atropine sulfate ointment-ophthalmic safe to take if I'm pregnant or breastfeeding?

There are no adequate and well-controlled studies of atropine sulfate in pregnant women

Small amounts of atropine were detected in human milk following administration of injectable atropine. Ophthalmic preparations of atropine are compatible with breastfeeding.

What else should I know about atropine sulfate ointment-ophthalmic?

What preparations of atropine sulfate ointment-ophthalmic are available?

Ophthalmic solution: 1%

How should I keep atropine sulfate ointment-ophthalmic stored?

Atropine ophthalmic solution can be stored in the refrigerator or at room temperature away from heat and light.

REFERENCE: FDA Prescribing Information.

Last Editorial Review: 6/16/2015

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Reviewed on 6/16/2015
References
REFERENCE: FDA Prescribing Information.

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