Treatment of malaria:
Adults: Take 4 tablets (1000 – 400 mg) by mouth as a single dose daily for 3 days.
Pediatric: Treatment doses are based on child's weight.
- Weight 5 to 8 kg: Take 2 pediatric tablets (125/50 mg) by mouth daily for 3 days.
- Weight 9 to 10 kg: Take 3 pediatric tablets (187.5/75 mg) by mouth daily for 3 days
- Weight 11 to 20 kg: Take 1 adult tablet (250/100 mg) by mouth daily for 3 days.
- Weight 21 to 30 kg: Take 2 adult tablets (500/200 mg) by mouth daily for 3 days.
- Weight 31 to 40 kg: Take 3 adult tablets (750/300 mg) by mouth daily for 3 days.
- Weight > 40 kg: Take 4 tablets (1000/400 mg) by mouth daily for 3 days.
Concomitant use of atovaquone/proguanil and rifampin or rifabutin can lower atovaquone levels approximately 50% and 34%, reducing effectiveness of malarial medication.
PREGNANCY: There are no adequate studies of atovaquone and proguanil to determine safe and effective use in pregnant women.
Medically reviewed by Eni Williams, PharmD
REFERENCE: FDA Prescribing Information.
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