atovaquone and proguanil (Malarone) oral (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Atovaquone and proguanil tablets are available in two combination strengths: 250/100 mg (adults) and 62.5/25 mg (pediatric).

STORAGE: Store Atovaquone and proguanil tablets should be stored between 15 C to 30 C (59 F to 86 F).

DOSING:

Prevention of malaria:

Adults: Take 1 tablet (250 – 100 mg) by mouth daily, starting 1 or 2 days before entering in malaria-endemic area; continue during the stay and for 7 days after return.

Pediatric: Preventive doses are based on a child's weight. All doses should be started 1 or 2 days before entering in malaria-endemic area; continued during the stay and for 7 days after return.

  • Weight 11 to 20 kg: Take 1 tablet (62.5/25 mg) by mouth daily.
  • Weight 21 to 30 kg: Take 2 tablets (125/50 mg) by mouth daily.
  • Weight 31 to 40 kg: Take 3 tablets (187.5/75 mg) by mouth daily.
  • Weight > 40 kg: Take 4 pediatric tablets (250/100 mg) OR 1 adult strength tablet (250/100 mg) by mouth daily.

Treatment of malaria:

Adults: Take 4 tablets (1000 – 400 mg) by mouth as a single dose daily for 3 days.

Pediatric: Treatment doses are based on child's weight.

  • Weight 5 to 8 kg: Take 2 pediatric tablets (125/50 mg) by mouth daily for 3 days.
  • Weight 9 to 10 kg: Take 3 pediatric tablets (187.5/75 mg) by mouth daily for 3 days
  • Weight 11 to 20 kg: Take 1 adult tablet (250/100 mg) by mouth daily for 3 days.
  • Weight 21 to 30 kg: Take 2 adult tablets (500/200 mg) by mouth daily for 3 days.
  • Weight 31 to 40 kg: Take 3 adult tablets (750/300 mg) by mouth daily for 3 days.
  • Weight > 40 kg: Take 4 tablets (1000/400 mg) by mouth daily for 3 days.

DRUG INTERACTIONS: Combining atovaquone/proguanil with tetracycline can lower atovaquone levels in the body, leading to lack of effectiveness of the antimalarial medication.

Concomitant use of atovaquone/proguanil and rifampin or rifabutin can lower atovaquone levels approximately 50% and 34%, reducing effectiveness of malarial medication.

Concomitant use of atovaquone/proguanil and metoclopramide (Reglan, Reglan ODT, Metozol ODT, Octamide) may lower the amount of atovaquone that the body can absorb, leading to lack of effectiveness.

Medically Reviewed by a Doctor on 9/10/2015


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