atovaquone and proguanil (Malarone) oral (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
Treatment of malaria:
Adults: Take 4 tablets (1000 – 400 mg) by mouth as a single dose daily for 3 days.
Pediatric: Treatment doses are based on child's weight.
Concomitant use of atovaquone/proguanil and rifampin or rifabutin can lower atovaquone levels approximately 50% and 34%, reducing effectiveness of malarial medication.
Concomitant use of atovaquone/proguanil and metoclopramide (Reglan, Reglan ODT, Metozol ODT, Octamide) may lower the amount of atovaquone that the body can absorb, leading to lack of effectiveness.
PREGNANCY: There are no adequate studies of atovaquone and proguanil to determine safe and effective use in pregnant women.
NURSING MOTHERS: It is not known if atovaquone enters breast milk, but proguanil may enter breast milk in trace amounts. It is best to exercise caution before using these drugs in nursing mothers.
SIDE EFFECTS: Side effects of atovaquone and proguanil are headache, fever, dizziness, myalgia, nausea and vomiting, diarrhea, abdominal pain, loss of appetite, cough, upper respiratory infections, and itching.
REFERENCE: FDA Prescribing Information.
Medically Reviewed by a Doctor on 5/16/2014
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