atovaquone and proguanil (Malarone) oral

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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Treatment of malaria:

Adults: Take 4 tablets (1000 – 400 mg) by mouth as a single dose daily for 3 days.

Pediatric: Treatment doses are based on child's weight.

  • Weight 5 to 8 kg: Take 2 pediatric tablets (125/50 mg) by mouth daily for 3 days.
  • Weight 9 to 10 kg: Take 3 pediatric tablets (187.5/75 mg) by mouth daily for 3 days
  • Weight 11 to 20 kg: Take 1 adult tablet (250/100 mg) by mouth daily for 3 days.
  • Weight 21 to 30 kg: Take 2 adult tablets (500/200 mg) by mouth daily for 3 days.
  • Weight 31 to 40 kg: Take 3 adult tablets (750/300 mg) by mouth daily for 3 days.
  • Weight > 40 kg: Take 4 tablets (1000/400 mg) by mouth daily for 3 days.

DRUG INTERACTIONS: Combining atovaquone/proguanil with tetracycline can lower atovaquone levels in the body, leading to lack of effectiveness of the antimalarial medication.

Concomitant use of atovaquone/proguanil and rifampin or rifabutin can lower atovaquone levels approximately 50% and 34%, reducing effectiveness of malarial medication.

Concomitant use of atovaquone/proguanil and metoclopramide (Reglan, Reglan ODT, Metozol ODT, Octamide) may lower the amount of atovaquone that the body can absorb, leading to lack of effectiveness.

PREGNANCY: There are no adequate studies of atovaquone and proguanil to determine safe and effective use in pregnant women.

NURSING MOTHERS: It is not known if atovaquone enters breast milk, but proguanil may enter breast milk in trace amounts. It is best to exercise caution before using these drugs in nursing mothers.

Medically reviewed by Eni Williams, PharmD

REFERENCE: FDA Prescribing Information.

Medically Reviewed by a Doctor on 9/10/2015

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