GENERIC NAME: Atovaquone and proguanil hydrochloride
BRAND NAME: Malarone
DRUG CLASS AND MECHANISM: Atovaquone and proguanil is an anti-malarial medication. Atovaquone blocks mitochondrial electron transfer and thereby the production of energy for use by the parasites. Proguanil is metabolized into its active metabolite, cycloguanil, which blocks dihydrofolate reductase and enzymes required for making pyrimidine which is a chemical needed for production of DNA.
SIDE EFFECTS: Common side effects of atovaquone and proguanil are:
- abdominal pain,
- loss of appetite,
- upper respiratory infections, and
GENERIC AVAILABLE: Yes
PREPARATIONS: Atovaquone and proguanil tablets are available in two combination strengths: 250/100 mg (adults) and 62.5/25 mg (pediatric).
STORAGE: Store Atovaquone and proguanil tablets should be stored between 15 C to 30 C (59 F to 86 F).
Prevention of malaria:
Adults: Take 1 tablet (250 – 100 mg) by mouth daily, starting 1 or 2 days before entering in malaria-endemic area; continue during the stay and for 7 days after return.
Pediatric: Preventive doses are based on a child's weight. All doses should be started 1 or 2 days before entering in malaria-endemic area; continued during the stay and for 7 days after return.
- Weight 11 to 20 kg: Take 1 tablet (62.5/25 mg) by mouth daily.
- Weight 21 to 30 kg: Take 2 tablets (125/50 mg) by mouth daily.
- Weight 31 to 40 kg: Take 3 tablets (187.5/75 mg) by mouth daily.
- Weight > 40 kg: Take 4 pediatric tablets (250/100 mg) OR 1 adult strength tablet (250/100 mg) by mouth daily.
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