atovaquone and proguanil (Malarone) oral

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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GENERIC NAME: Atovaquone and proguanil hydrochloride

BRAND NAME: Malarone

DRUG CLASS AND MECHANISM: Atovaquone and proguanil is an anti-malarial medication. Atovaquone blocks mitochondrial electron transfer and thereby the production of energy for use by the parasites. Proguanil is metabolized into its active metabolite, cycloguanil, which blocks dihydrofolate reductase and enzymes required for making pyrimidine which is a chemical needed for production of DNA.

PRESCRIBED FOR: Atovaquone and proguanil is used for prevention and treatment of P. Falciparum malaria.

SIDE EFFECTS: Common side effects of atovaquone and proguanil are:

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Atovaquone and proguanil tablets are available in two combination strengths: 250/100 mg (adults) and 62.5/25 mg (pediatric).

STORAGE: Store Atovaquone and proguanil tablets should be stored between 15 C to 30 C (59 F to 86 F).

DOSING:

Prevention of malaria:

Adults: Take 1 tablet (250 – 100 mg) by mouth daily, starting 1 or 2 days before entering in malaria-endemic area; continue during the stay and for 7 days after return.

Pediatric: Preventive doses are based on a child's weight. All doses should be started 1 or 2 days before entering in malaria-endemic area; continued during the stay and for 7 days after return.

  • Weight 11 to 20 kg: Take 1 tablet (62.5/25 mg) by mouth daily.
  • Weight 21 to 30 kg: Take 2 tablets (125/50 mg) by mouth daily.
  • Weight 31 to 40 kg: Take 3 tablets (187.5/75 mg) by mouth daily.
  • Weight > 40 kg: Take 4 pediatric tablets (250/100 mg) OR 1 adult strength tablet (250/100 mg) by mouth daily.
Medically Reviewed by a Doctor on 9/10/2015

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