atomoxetine, Strattera (cont.)

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Medical Editor:

Priapism defined as painful and nonpainful penile erection lasting more than 4 hours have been reported in pediatric and adult patients treated with stimulants. The erection usually resolves when the drug is stopped. Prompt medical attention is required in the event of suspected priapism.



PREPARATIONS: Capsules of 10, 18, 25, 40, 60, 80, and 100 mg strengths.

STORAGE: Atomoxetine capsules should be stored at room temperature, 59 F to 86 F (15 C to 30 C).

DOSING: Atomoxetine is taken once or twice daily. It may be taken with or without food. The capsules should never be broken and sprinkled on food. They must be taken whole.

DRUG INTERACTIONS: Atomoxetine should not be taken with a monoamine oxidase inhibitor (MAOI) or within 14 days of stopping an MAOI, for example, phenelzine sulfate (Nardil) and tranylcypromine sulfate (Parnate).

Fluoxetine (Prozac), paroxetine (Paxil), quinidine, and other medications can block the enzyme in the liver that eliminates atomoxetine from the body. This can increase the amount of atomoxetine in the blood and possibly increase the risk of side effects.

PREGNANCY: In some animal studies (rabbits and rats), very high doses of atomoxetine (6- to 23-fold higher than those that would be used in humans) were associated with lower birth weight and lower fetal survival. No adequate studies have been done in pregnant women. Therefore, before prescribing atomoxetine to pregnant women, physicians must weight the potential benefits against the potential and unknown risks.

NURSING MOTHERS: Atomoxetine is excreted in the breast milk of animals. Although not similarly studied in humans, it is likely that atomoxetine is excreted in human breast milk as well. The benefits and potential risks of atomoxetine therefore must be weighed before it is prescribed to nursing mothers.

Medically reviewed by Eni Williams, PharmD

Reference: FDA Prescribing Information

Medically Reviewed by a Doctor on 4/6/2015

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