atenolol and chlorthalidone, Tenoretic

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

View the High Blood Pressure (Hypertension) Slideshow Pictures



PREPARATIONS: Tablets: atenolol 50mg and chlorthalidone 25mg; atenolol 100mg and chlorthalidone 25mg.

STORAGE: Tablets should be stored at room temperature, 15C and 30 C (59 F and 86 F).

DOSING: The recommended dose of atenolol/chlorthalidone is one tablet once daily starting with 50 mg/25 mg then increasing to 100 mg/25 mg if blood pressure control is not adequate.


  • Chlorthalidone can lower blood potassium and magnesium levels because both potassium and magnesium are lost in the urine.
  • Chlorthalidone reduces the kidney's ability to eliminate lithium (Lithobid) in the urine. As a result, patients taking chlorthalidone at the same time as drugs containing lithium may develop high levels of lithium and/or lithium toxicity.
  • Atenolol can mask the early warning symptoms of low blood sugar (hypoglycemia), and should be used with caution in patients receiving treatment for diabetes. Combining atenolol with other drugs that reduce blood pressure or slow heart rate may lead to excessive blood pressure reduction or low heart rate.

PREGNANCY: Atenolol/chlorthalidone should not be used during pregnancy because atenolol can cause fetal harm.

NURSING MOTHERS: Atenolol is excreted in breast milk and may adversely affect the infant. Atenolol/chlorthalidone should be avoided while breastfeeding.

Reference: FDA Prescribing Information

Medically Reviewed by a Doctor on 12/9/2014

Quick GuideLowering Blood Pressure Pictures Slideshow: Exercise Tips for Getting Started

Lowering Blood Pressure Pictures Slideshow: Exercise Tips for Getting Started
FDA Logo

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

RxList Logo

Need help identifying pills and medications?

Use the pill identifier tool on RxList.

Subscribe to MedicineNet's Heart Health Newsletter

By clicking Submit, I agree to the MedicineNet's Terms & Conditions & Privacy Policy and understand that I may opt out of MedicineNet's subscriptions at any time.

Health Solutions From Our Sponsors