What Are the Side Effects of Acetaminophen?

  • Medical Author:
    Standiford Helm II, MD

    Dr. Helm has been practicing interventional pain management since 1982. Dr. Helm is a diplomate of the American Board of Anesthesiology with subspecialty certification in Pain Medicine and of the American Board of Pain Medicine. Dr. Helm is a Fellow of Interventional Pain Practice (FIPP), the only certifying agency which tests the ability to perform interventional pain procedures. Dr. Helm is also an examiner for FIPP.

  • Medical Editor: Melissa Conrad Stöppler, MD
    Melissa Conrad Stöppler, MD

    Melissa Conrad Stöppler, MD

    Melissa Conrad Stöppler, MD, is a U.S. board-certified Anatomic Pathologist with subspecialty training in the fields of Experimental and Molecular Pathology. Dr. Stöppler's educational background includes a BA with Highest Distinction from the University of Virginia and an MD from the University of North Carolina. She completed residency training in Anatomic Pathology at Georgetown University followed by subspecialty fellowship training in molecular diagnostics and experimental pathology.

A Guide to Migraine Headaches

Ask the experts

I have been diagnosed with a mild form of migraine along with tension headache. I experience mild to strong headaches approximately twice a month, for which I take Paracetamol or Anacin - my dosage comes to about 10 tablets a month. My question is - can these have harmful effects in the long run? I have been taking this medication for the last 10 years.

Doctor's response

Paracetamol is also known as acetaminophen in the United States and is marketed as Tylenol, along with other product names. Anacin is a combination of aspirin and caffeine. Both are effective medications and both have potentially harmful side effects. Paracetamol can, through its breakdown products, cause damage to the liver and kidney. Generally, doses should be kept below four grams per day, although some physicians believe that, when used chronically, the dose should be kept below two grams per day.

Aspirin's most common side effect is gastric upset and ulceration. It also interferes with blood clotting, which is why it is used to help prevent heart disease. With large toxic doses, it can cause life-threatening problems with acidosis (excessive acid in the fluids and tissues of the body) A standard maximum daily dosage is six 325 mg pills per day. These drugs can also, in large doses, cause difficulty with hearing including tinnitus and deafness.

Either way, taking 10 tablets a month for a long time seems reasonable. You should let your family physician know what you are taking so that he or she can monitor you for side effects and possible drug interactions. In addition, you need to be aware of what is in other over-the-counter medications that you take to make sure that they do not have either paracetamol or aspirin in them, making your daily intake of these medications higher than you think.

Medically reviewed by John A. Daller, MD; American Board of Surgery with subspecialty certification in surgical critical care


FDA Prescribing Information

Quick GuideMigraine or Headache? Migraine Symptoms, Triggers, Treatment

Migraine or Headache? Migraine Symptoms, Triggers, Treatment

Subscribe to MedicineNet's General Health Newsletter

By clicking Submit, I agree to the MedicineNet's Terms & Conditions & Privacy Policy and understand that I may opt out of MedicineNet's subscriptions at any time.

Reviewed on 8/4/2017

Health Solutions From Our Sponsors