Do Diuretics Interact with Vicodin?

Medical Author:
Medical Editor:

Ask the experts

Do diuretics decrease the effectiveness of Vicodin?

Doctor's response

There should not be any interaction between diuretics and hydrocodone/acetaminophen (Vicodin). If the Vicodin is not working, you should look to other causes than the diuretic.

Medically reviewed by John A. Daller, MD; American Board of Surgery with subspecialty certification in surgical critical care


"Cancer pain management: Use of acetaminophen and nonsteroidal antiinflammatory drugs"

Medically Reviewed by a Doctor on 8/2/2017

Health Solutions From Our Sponsors