armodafinil (Nuvigil)

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GENERIC NAME: armodafinil

BRAND NAME: Nuvigil

DRUG CLASS AND MECHANISM: Armodafinil is an oral drug that is used to promote wakefulness. It is similar to modafinil (Provigil). Like amphetamines, armodafinil promotes wakefulness by stimuatIng the brain; however, the exact mechanism of action of armodafinil is unknown. Armodafinil may work by increasing the amount of dopamine (a chemical neurotransmitter that nerves use to communicate with each other) in the brain by reducing the reuptake of dopamine into nerves. The FDA approved armodafinil in June 2007.

PRESCRIPTION: Yes

GENERIC AVAILABLE: No

PREPARATIONS: Tablets: 50, 150, 250 mg.

STORAGE: Armodafinil should be stored at room temperature, 20-30 C (68-77 F).

PRESCRIBED FOR: Armodafinil is prescribed for improving wakefulness associated with obstructive sleep apnea/hypoapnea syndrome, narcolepsy, and shift work sleep disorder.

DOSING: The recommended dose is 150 or 250 mg every morning or 150 mg daily one hour prior to the work shift.

DRUG INTERACTIONS: Armodafinil can decrease or increase the activity of enzymes in the liver that metabolize (eliminate) other drugs. This can result in decreased levels of some drugs that reduce their effectiveness as well as increased levels of other drugs that increase their toxicity. Armodafinil treatment should be carefully monitored if taken with any of these drugs.




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