aripiprazole, Abilify (cont.)

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Long-term use of aripiprazole may lead to a potentially irreversible condition called tardive dyskinesia (involuntary movements of the jaw, lips, and tongue).

A potentially fatal complex referred to as neuroleptic malignant syndrome has been reported with anti-psychotic drugs, including aripiprazole. Patients who develop this syndrome may have:

  • high fevers,
  • muscle rigidity,
  • altered
  • mental status,
  • irregular pulse or blood pressure,
  • rapid heart rate,
  • excessive sweating, and
  • heart arrhythmias.

Although there is no clear link between aripiprazole and diabetes, patients should be tested during treatment for elevated blood-sugars. Additionally, persons with risk factors for diabetes, including obesity or a family history of diabetes, should have their fasting levels of blood sugar tested before starting treatment and periodically throughout treatment to detect the onset of diabetes. Any patient developing symptoms that suggest diabetes during treatment should be tested for diabetes.

Elderly patients with dementia related psychosis treated with antipsychotics are at an increased risk of death and aripiprazole should not be used for this indication.

Antidepressants increased the risk of suicidal thinking and behavior in short-term studies in children and adolescents with depression and other psychiatric disorders. Anyone considering the use of aripiprazole or any other antidepressant in a child or adolescent must balance this risk of suicide with the clinical need. Patients who are started on therapy should be closely observed for clinical worsening, suicidal thoughts, or unusual changes in behavior.




  • Tablets: 10, 15, 20, and 30 mg.
  • Tablets (Disintegrating): 10 and 15 mg.
  • Oral solution: 1 mg/mL.
  • Injection Solution: 9.75 mg/1.3 ml.
  • Extended release Injection: 300 or 400 mg/vial

STORAGE: Tablets should be stored at room temperature, 15 C to 30 C (59 F to 86 F).

DOSING: Aripiprazole usually is taken once a day. The usual adult starting oral dose for schizophrenia or bipolar disorder is 10 to 15 mg once daily. The dose may be increased over time up to 30 mg daily to achieve the desired effect.

Medically Reviewed by a Doctor on 7/29/2014

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