- What is Abilify, and how does it work (mechanism of action)?
- Is this medication available as a generic drug?
- Do I need a prescription this medication?
- What are the uses for Abilify?
- Abilify warnings and side effects
- What is the dosage for Abilify?
- Abilify drug, food (grapefruit juice), and supplement interactions
- Is it safe to take this drug if I'm pregnant or breastfeeding my baby?
- What else should I know about this drug?
What is Abilify, and how does it work (mechanism of action)?
This drug also is used with other medications for the treatment of major depression in adults.
The exact mechanism of action of Abilify is unknown. Moreover, like other anti-psychotics, it blocks several receptors on the nerves of the brain for several neurotransmitters (chemicals that nerves use to communicate with each other). It is thought that its beneficial effect is due to its effects on dopamine and serotonin receptors. Its effects on these receptors are complex, involving stimulation of the receptors but to a lesser degree than the naturally-occurring neurotransmitters (a process called partial agonism).
Is this medication available as a generic drug?
No, this medication is not available in generic form.
Do I need a prescription for this medication?
Yes, you need a doctor or other medical health professional to write a prescription for this drug.
What are the uses for Abilify?
Aripiprazole is used for the treatment of:
- Bipolar disorder
- Irritability associated with autistic disorder
- Tourette's disorder
- Major depression in adults (along with other medications used for the treatment of depression)
- Mixed manic/depressive episodes (as sole or adjunctive therapy) and as adjunctive (add-on) therapy for major depressive disorder
- Agitation associated with schizophrenia or bipolar mania.
Abilify warnings and side effects
- Long-term use of aripiprazole may lead to a potentially irreversible condition called tardive dyskinesia (involuntary movements of the jaw, lips, and tongue).
- A potentially fatal complex referred to as neuroleptic malignant syndrome has been reported with anti-psychotic drugs, including Abilify. Patients who develop this syndrome may have:
- All atypical antipsychotic drugs have been associated with metabolic changes such as hyperglycemia, diabetes mellitus, dyslipidemia, and weight gain. Serious cases of hyperglycemia leading to coma or death have been reported in patients treated with atypical antipsychotics. Although there is no clear link between aripiprazole and diabetes, patients should be tested during treatment for elevated blood-sugars. Additionally, patients with risk factors for diabetes, including obesity or a family history of diabetes, should have their fasting levels of blood sugar tested before starting treatment and periodically throughout treatment to detect the onset of diabetes. Any patient developing symptoms that suggest diabetes during medical treatment should be tested for diabetes.
- Elderly patients with dementia related psychosis treated with antipsychotics are at an increased risk of death and Abilify should not be used for this indication. Antidepressants increased the risk of suicidal thinking and behavior in short-term studies in children and adolescents with depression and other psychiatric disorders. Anyone considering the use of this medicine or any other antidepressant in a child or adolescent must balance this risk of suicide with the clinical need. Patients who are started on medical therapy should be closely observed for clinical worsening, suicidal thoughts, or unusual changes in behavior.
Some of the most common side effects
- Blurred vision
- Runny nose
- Weight gain
Quick GuidePhysical Symptoms of Depression in Pictures
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