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November 23, 2009
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ARDS (cont.)

What Causes ARDS?

The causes of acute respiratory distress syndrome (ARDS) are not well understood. It can occur in many situations and in persons with or without a lung disease.

There are two ways that lung injury leading to ARDS can occur: through a direct injury to the lungs, or indirectly when a person is very sick or has a serious bodily injury. However, most sick or badly injured persons do not develop ARDS.

Direct Lung Injury

A direct injury to the lungs may result from breathing in harmful substances or an infection in the lungs. Some direct lung injuries that can lead to ARDS include:

  • Breathing in vomited stomach contents
  • Breathing in harmful fumes or smoke
  • A severe blow to the chest or other accident that bruises the lungs

Indirect Lung Injury

Most cases of ARDS happen in people who are very ill or who have been in a major accident. This is sometimes called an indirect lung injury. Less is known about how indirect injuries lead to ARDS than about how direct injuries to the lungs cause ARDS. Indirect lung injury leading to ARDS sometimes occurs in cases of:

  • Severe and widespread bacterial infection in the body (sepsis)
  • Severe injury with shock
  • Severe bleeding requiring blood transfusions
  • Drug overdose

It is not clear why some very sick or seriously injured people develop ARDS, and others do not. Researchers are trying to find out why ARDS develops and how to prevent it.



Next: Who is at risk for ARDS? »

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