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- What is apremilast, and how does it work (mechanism of action)?
- What brand names are available for apremilast?
- Is apremilast available as a generic drug?
- Do I need a prescription for apremilast?
- What are the side effects of apremilast?
- What is the dosage for apremilast?
- Which drugs or supplements interact with apremilast?
- Is apremilast safe to take if I'm pregnant or breastfeeding?
- What else should I know about apremilast?
What is apremilast, and how does it work (mechanism of action)?
Apremilast is an oral medication used to treat adults with active psoriatic arthritis (a form of arthritis that affects some people with psoriasis). It is also used to treat moderate to severe plaque psoriasis in patients who are candidates for phototherapy or systemic therapy. Apremilast works by reducing production of an enzyme known as phosphodiesterase 4(PDE4). This may lead to a reduction in chemicals that cause inflammation in the body. However the exact mechanism in treating psoriatic arthritis and plaque psoriasis is not known. In clinical studies, patients with psoriatic arthritis had improvement in tender and swollen joints, as well as physical function. Patients with plaque psoriasis had reductions in redness, scaliness and thickness of the skin. The FDA approved apremilast in March 2014.
What brand names are available for apremilast?
Is apremilast available as a generic drug?
GENERIC AVAILABLE: No
Do I need a prescription for apremilast?
What are the side effects of apremilast?
The most common side effects associated with apremilast are diarrhea, nausea, and headache. It also can cause upper respiratory tract infections. Depression, upper abdominal pain, and weight loss were also reported in clinical studies.
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