Abnormal: Not normal. Deviating from the usual structure, position, condition, or behavior. In referring to a growth, abnormal may mean that it is cancerous or premalignant (likely to become cancer ).
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Addison disease: Long-term underfunction of the outer portion of the adrenal gland. In medical terms, chronic insufficiency of the adrenal cortex. This may be due to a number of different insults to the adrenal including physical trauma, hemorrhage, and tuberculosis of the adrenal, and destruction of the cells in the pituitary gland that secrete ACTH (adrenocorticotropic hormone) which normally drives the adrenal. Addison's disease is characterized by bronzing of the skin, anemia, weakness, and low blood pressure. The U.S. President J.F. Kennedy is said to have had Addison disease. Named after the British physician Thomas Addison (1793-1860).When Addison first identified adrenal insufficiency in 1849, tuberculosis (TB) was responsible for 70-90% of cases. As the treatment for TB improved, the incidence of adrenal insufficiency due to TB of the adrenal glands greatly decreased. TB now accounts for around 20% of cases of primary adrenal insufficiency in developed countries.
Anemia: The condition of having less than the normal number of red blood cells or less than the normal quantity of hemoglobin in the blood. The oxygen-carrying capacity of the blood is, therefore, decreased.
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Anti-: Prefix generally meaning "against, opposite or opposing, and contrary." In medicine, anti- often connotes "counteracting or effective against" as in antibacterial, anti-infective, and antiviral. Sometimes medical terms containing anti- take on new meanings as has occurred with antibiotic and antibody. As a prefix, anti- may be shortened to ant- as in antacid. "Anti" is the Greek word for "against."
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Antibody: An immunoglobulin, a specialized immune protein , produced because of the introduction of an antigen into the body, and which possesses the remarkable ability to combine with the very antigen that triggered its production.
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Antinuclear antibody: An unusual antibody that is directed against structures within the nucleus of the cell. Antinuclear antibodies (ANAs) are found in patients whose immune system is predisposed to cause inflammation against their own body tissues. Antibodies that are directed against one's own tissues are referred to as autoantibodies. The propensity for the immune system to work against its own body is referred to as autoimmunity . ANAs indicate the possible presence of autoimmunity.
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Antinuclear antibody test: A test for unusual antibodies that are directed against structures within the nucleus of the cell. Antinuclear antibodies (ANAs) indicate the possible presence of autoimmunity.
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Arthritis: Inflammation of a joint. When joints are inflamed they can develop stiffness, warmth, swelling, redness and pain. There are over 100 types of arthritis. (see osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, lupus, gout, pseudogout).
Autoimmune: Pertaining to autoimmunity, a misdirected immune response that occurs when the immune system goes awry and attacks the body itself.
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Autoimmune disease: An illness that occurs when the body tissues are attacked by its own immune system . The immune system is a complex organization within the body that is designed normally to "seek and destroy" invaders of the body, including infectious agents. Patients with autoimmune diseases frequently have unusual antibodies circulating in their blood that target their own body tissues.
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Autoimmunity: A misdirected immune response that occurs when the immune system goes awry and attacks the body itself.
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Bacteria: Single-celled microorganisms which can exist either as independent (free-living) organisms or as parasites (dependent upon another organism for life).
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Biliary: Having to do with the gallbladder , bile ducts , or bile. The biliary system itself consists of the gallbladder and bile ducts and, of course, the bile.
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Blood: The familiar red fluid in the body that contains white and red blood cells, platelets, proteins, and other elements. The blood is transported throughout the body by the circulatory system. Blood functions in two directions: arterial and venous. Arterial blood is the means by which oxygen and nutrients are transported to tissues while venous blood is the means by which carbon dioxide and metabolic by-products are transported to the lungs and kidneys, respectively, for removal from the body.
Breast : The breast refers to the front of the chest or, more specifically, to the mammary gland. The mammary gland is a milk producing gland. It is composed largely of fat. Within the mammary gland is a complex network of branching ducts. These ducts exit from sac-like structures called lobules, which can produce milk in females. The ducts exit the breast at the nipple.
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Cancer: An abnormal growth of cells which tend to proliferate in an uncontrolled way and, in some cases, to metastasize (spread).
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Cell: The basic structural and functional unit in people and all living things. Each cell is a small container of chemicals and water wrapped in a membrane .
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Chronic: This important term in medicine comes from the Greek chronos, time and means lasting a long time.
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Cirrhosis: An abnormal liver condition characterized by irreversible scarring of the liver. Alcohol and viral hepatitis B and C are among the many causes of cirrhosis. Cirrhosis can cause yellowing of the skin (jaundice), itching, and fatigue. Diagnosis of cirrhosis can be suggested by physical examination and blood tests, and can be confirmed by liver biopsy in some patients. Complications of cirrhosis include mental confusion, coma, fluid accumulation (ascites), internal bleeding, and kidney failure. Treatment of cirrhosis is designed to limit any further damage to the liver as well as complications. Liver transplantation is becoming an important option for patients with advanced cirrhosis.
Clinical: 1. Having to do with the examination and treatment of patients. 2. Applicable to patients. A laboratory test may be of clinical value (of use to patients).
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Colitis: Inflammation of the large intestine (the colon). There are many forms of colitis, including ulcerative, Crohn's, infectious, pseudomembranous, and spastic. For example, intermittent rectal bleeding, crampy abdominal pain and diarrhea can be symptoms of ulcerative colitis. Diagnosis can be made by barium enema, but direct visualization (sigmoidoscopy or colonoscopy) is the most accurate test. Long-standing ulcerative colitis increases the risk for colon cancer. Ulcerative colitis can also be associated with inflammation in joints, spine, skin, eyes, the liver and its bile ducts. Treatment of ulcerative colitis can involve medications and surgery.
Diabetes: Refers to diabetes mellitus or, less often, to diabetes insipidus . Diabetes mellitus and diabetes insipidus share the name "diabetes" because they are both conditions characterized by excessive urination (polyuria).
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Diabetes mellitus: Better known just as " diabetes " -- a chronic disease associated with abnormally high levels of the sugar glucose in the blood. Diabetes is due to one of two mechanisms:
(1) Inadequate production of insulin (which is made by the pancreas and lowers blood glucose) or
(2) Inadequate sensitivity of cells to the action of insulin.
The two main types of diabetes correspond to these two mechanisms and are called insulin dependent (type 1) and non-insulin dependent (type 2) diabetes. In type 1 diabetes there is no insulin or not enough of it. In type 2 diabetes, there is generally enough insulin but the cells upon it should act are not normally sensitive to its action.
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Disease: Illness or sickness often characterized by typical patient problems (symptoms) and physical findings (signs). Disruption sequence: The events that occur when a fetus that is developing normally is subjected to a destructive agent such as the rubella (German measles) virus.
DNA: Deoxyribonucleic acid. One of two types of molecules that encode genetic information. (The other is RNA . In humans DNA is the genetic material; RNA is transcribed from it. In some other organisms, RNA is the genetic material and, in reverse fashion, the DNA is transcribed from it.)
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Family: 1. A group of individuals related by blood or marriage or by a feeling of closeness. 2. A biological classification of related plants or animals that is a division below the order and above the genus. 3. A group of genes related in structure and in function that descended from an ancestral gene. 4. A group of gene products similarly related in structure and function and of shared genetic descent. 5. Parents and their children. The most fundamental social group in humans.
Family history: The family structure and relationships within the family, including information about diseases in family members.
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Gastrointestinal: Adjective referring collectively to the stomach and small and large intestines.
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Genetic: Having to do with genes and genetic information.
Hemolytic: Referring to hemolysis, the destruction of red blood cells which leads to the release of hemoglobin from within the red blood cells into the blood plasma .
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Hypertension: High blood pressure , defined as a repeatedly elevated blood pressure exceeding 140 over 90 mmHg -- a systolic pressure above 140 with a diastolic pressure above 90.
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Idiopathic: Of unknown cause. Any disease that is of uncertain or unknown origin may be termed idiopathic. For example, acute idiopathic polyneuritis , diffuse idiopathic skeletal hyperostosis , idiopathic pulmonary fibrosis , idiopathic scoliosis , etc.
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Idiopathic thrombocytopenic purpura: A "wastepaper basket" for those cases of immune thrombocytopenic purpura whose cause is still unknown. See: Immune thrombocytopenic purpura.
Immune: Protected against infection. The Latin immunis means free, exempt.
Immune system: A complex system that is responsible for distinguishing us from everything foreign to us, and for protecting us against infections and foreign substances. The immune system works to seek and kill invaders.
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Indicate: In medicine, to make a treatment or procedure advisable because of a particular condition or circumstance. For example, certain medications are indicated for the treatment of hypertension during pregnancy while others are contraindicated.
Indication: 1. In medicine, a condition which makes a particular treatment or procedure advisable. CML (chronic myeloid leukemia) is an indication for the use of Gleevec (imatinib mesylate). 2. A sign or a circumstance which points to or shows the cause, pathology, treatment, or outcome of an attack of disease. The presence of the Philadelphia chromosome in peripheral blood cells is an indication of a relapse in CML.
Inflammation: A basic way in which the body reacts to infection , irritation or other injury, the key feature being redness, warmth, swelling and pain . Inflammation is now recognized as a type of nonspecific immune response .
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Juvenile: Between infantile and adult as, for example, in juvenile rheumatoid arthritis (onset before age 16 years) and juvenile diabetes (type 1 diabetes).
Kidney: One of a pair of organs located in the right and left side of the abdomen which clear "poisons" from the blood, regulate acid concentration and maintain water balance in the body by excreting urine. The kidneys are part of the urinary tract. The urine then passes through connecting tubes called "ureters" into the bladder. The bladder stores the urine until it is released during urination.
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Laboratory: A place for doing tests and research procedures and preparing chemicals, etc. Although "laboratory" looks very like the Latin "laboratorium" (a place to labor, a work place), the word "laboratory" came from the Latin "elaborare" (to work out, as a problem, and with great pains), as evidenced by the Old English spelling "elaboratory" designating "a place where learned effort was applied to the solution of scientific problems."
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Liver: An organ in the upper abdomen that aids in digestion and removes waste products and worn-out cells from the blood. The liver is the largest solid organ in the body. The liver weighs about three and a half pounds (1.6 kilograms). It measures about 8 inches (20 cm) horizontally (across) and 6.5 inches (17 cm) vertically (down) and is 4.5 inches (12 cm) thick.
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Liver disease: Liver disease refers to any disorder of the liver. The liver is a large organ in the upper right abdomen that aids in digestion and removes waste products from the blood.
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Lupus: A chronic inflammatory condition caused by an autoimmune disease. An autoimmune disease occurs when the body's tissues are attacked by its own immune system. Patients with lupus have unusual antibodies in their blood that are targeted against their own body tissues.
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Melanoma : The most dangerous form of skin cancer, a malignancy of the melanocyte, the cell that produces pigment in the skin. Melanoma is most common in people with fair skin, but can occur in people with all skin colors. Most melanomas present as a dark, mole-like spot that spreads and, unlike a mole, has an irregular border. The tendency toward melanoma may be inherited, and the risk increases with overexposure to the sun and sunburn.
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Nucleus: 1) In cell biology, the structure that houses the chromosomes. 2) In neuroanatomy, a group of nerve cells.
Ovarian: Of or pertaining to the ovary.
Pemphigus: One of a group of chronic , relapsing autoimmune skin diseases that cause blisters and erosions of the skin and mucous membranes. The immune system mistakenly regards the cells in the skin and mucous membranes as foreign and attacks them.
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Peripheral: Situated away from the center, as opposed to centrally located.
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Pernicious anemia : A blood disorder caused by inadequate vitamin B12 in the blood. Patients who have this disorder do not produce the substance in the stomach that allows the body to absorb vitamin B12. This substance is called intrinsic factor (IF).
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Polymyositis : A chronic inflammatory disease of muscle that begins when white blood cells , the immune cells of inflammation, spontaneously invade muscles, especially the muscles closest to the trunk or torso, resulting in sometimes severe muscle pain, tenderness and weakness.
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Primary: First or foremost in time or development. The primary teeth (the baby teeth) are those that come first. Primary may also refer to symptoms or a disease to which others are secondary.
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Psoriasis : A reddish, scaly rash often located over the surfaces of the elbows, knees, scalp, and around or in the ears, navel, genitals or buttocks. Psoriasis is an autoimmune disease that is mediated by T lymphocytes. It is also a very common disease, Chronic plaque psoriasis affects approximately 2% of people around the world. About 10-15% of patients with psoriasis develop joint inflammation (inflammatory arthritis ). Treatment options include topical steroid creams, tar soap preparations, and exposure to ultraviolet light.
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Pulmonary: Having to do with the lungs. (The word comes from the Latin pulmo for lung).
Pulmonary fibrosis: Scarring throughout the lungs which can be caused by many conditions such as, sarcoidosis , hypersensitivity pneumonitis , asbestosis, and certain medications. Pulmonary fibrosis can also occur without an identifiable cause, in which case it is referred to as idiopathic pulmonary fibrosis . Symptoms include shortness of breath, coughing and diminished exercise tolerance. Treatment involves the use of corticosteroids (such as prednisone ) and/or other medications that suppress the body's immune system. Interferon gamma-1b treatment may help patients with idiopathic pulmonary fibrosis who do not respond to corticosteroid therapy. The goal of treatment is to decrease lung inflammation and subsequent scarring. Responses to treatment vary. Toxicity and side effects of treatments can be serious. Therefore, patients with pulmonary fibrosis are generally cared for by lung specialists.
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Purpura: 1. A hemorrhagic area in the skin. The area of bleeding within the skin, by definition, is greater than 3 millimeters in diameter. The appearance of the purpura depends on age of the lesion. Early purpura is red and becomes darker, then purple, and brown-yellow as it fades. Purpura does not blanch when touched.
2. A condition characterized by purpura such as immune thrombocytopenic purpura and Schönlein-Henoch purpura.
Rheumatoid arthritis : An autoimmune disease which causes chronic inflammation of the joints, the tissue around the joints, as well as other organs in the body. Autoimmune diseases occur when the body tissues are mistakenly attacked by its own immune system. The immune system is a complex organization of cells and antibodies designed normally to "seek and destroy" invaders of the body, particularly infections. Patients with these diseases have antibodies in their blood which target their own body tissues, where they can be associated with inflammation. Because it can affect multiple other organs of the body, rheumatoid arthritis is referred to as a systemic illness and is sometimes called rheumatoid disease. While rheumatoid arthritis is a chronic illness (meaning it can last for years) patients may experience long periods without symptoms.
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Rheumatology: A subspecialty of internal medicine that involves the non-surgical evaluation and treatment of the rheumatic diseases and conditions. Rheumatic diseases and conditions are characterized by symptoms involving the musculoskeletal system. Many of the rheumatic diseases and conditions feature immune system abnormalities. Therefore, rheumatology also involves the study of the immune system. Classical rheumatology training includes 4 years of medical school, 1 year of internship in internal medicine, 2 years of internal medicine residency, and 2 years of rheumatology fellowship. There is a subspecialty board for rheumatology certification. The American College of Rheumatology is the official organization acting on behalf of the field of rheumatology in the United States.
Scleroderma: A disease of connective tissue with the formation of scar tissue (fibrosis) in the skin and sometimes also in other organs of the body.
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Serum: The clear liquid that can be separated from clotted blood. Serum differs from plasma, the liquid portion of normal unclotted blood containing the red and white cells and platelets. It is the clot that makes the difference between serum and plasma.
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Skin: The skin is the body's outer covering. It protects us against heat and light, injury, and infection. It regulates body temperature and stores water, fat, and vitamin D. Weighing about 6 pounds, the skin is the body's largest organ. It is made up of two main layers; the outer epidermis and the inner dermis.
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Syndrome: A set of signs and symptoms that tend to occur together and which reflect the presence of a particular disease or an increased chance of developing a particular disease.
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Systemic: Affecting the entire body. A systemic disease such as diabetes can affect the whole body. Systemic chemotherapy employs drugs that travel through the bloodstream and reach and affect cells all over the body.
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Thyroiditis : Inflammation of the thyroid gland which is located in front of the neck:
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Ulcerative colitis : A relatively common disease that causes inflammation of the large intestine (the colon). The cause is unknown.
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Virus: A microorganism smaller than a bacteria, which cannot grow or reproduce apart from a living cell. A virus invades living cells and uses their chemical machinery to keep itself alive and to replicate itself. It may reproduce with fidelity or with errors (mutations)-this ability to mutate is responsible for the ability of some viruses to change slightly in each infected person, making treatment more difficult.
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Vitiligo : Pronounced vit-uh-LIE- go. A condition in which the skin turns white due to the loss of melanocytes. These cells produce melanin, the pigment that gives the skin its characteristic color. (Melanocytes also impart color to the retina of the eye and the mucous membrane tissues lining the inside of the mouth, nose, genital and rectal areas). In vitiligo, the melanocytes are mysteriously destroyed, leaving de-pigmented patches of skin on different parts of the body. The hair that grows in areas affected by vitiligo may also turn white.
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- Rheumatoid Arthritis - Learn more about rheumatoid arthritis, an autoimmune disease that causes chronic joint inflammation, which has symptoms that include stiffness, fever, muscle and joint aches, loss of appetite, and fatigue. Treatment of rheumatoid arthritis incorporates the use of first-line drugs (aspirin and corticosteroids for pain and inflammation) and second-line drugs (methotrexate and hydroxychloroquine to prevent joint destruction and promote remission). Source:MedicineNet
- Lupus - Get information on lupus (SLE) disease treatment, signs, diagnosis, types of symptoms (butterfly, discoid rash), causes (genetic), pregnancy flares and statistics. Source:MedicineNet
- Sjogren's Syndrome - Learn about Sjogren's syndrome, an autoimmune disease involving the abnormal production of extra antibodies that attack the glands and connective tissue. Primary Sjogren's syndrome only affects the glands, while secondary Sjogren's syndrome also involves the connective tissue. Symptoms may include dry eyes, dry mouth, rheumatoid arthritis, lupus, or scleroderma. Though there is no cure for Sjogren's syndrome, the symptoms may be treated by using lubricating eye ointments, drinking plenty of water, humidifying the air, and using glycerin swabs. Medications are also available to treat dry eye and dry mouth. Source:MedicineNet
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