Antimitochondrial Antibodies (cont.)

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What is the value of the AMA blood test?

AMA are detectable in the serum in 95 to 98% of patients with PBC. So, AMA are tremendously important as a diagnostic marker in patients with PBC. The AMA titers in PBC are almost universally greater than or equal to 1 to 40. This means that a serum sample diluted with 40 times its original volume still contains enough antimitochondrial antibodies to be detected in the binding reaction. A positive AMA with a titer of at least 1:40 in an adult with an elevated alkaline phosphatase in the blood is highly specific for a diagnosis of PBC.

Medically reviewed by Venkatachala Mohan, MD; Board Certified Internal Medicine with subspecialty in Gastroenterology

REFERENCE:

"Clinical manifestations, diagnosis, and natural history of primary biliary cirrhosis"
uptodate.com


Medically Reviewed by a Doctor on 2/21/2014

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