Antihistamines (Oral) (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
In this Article
What formulations of oral antihistamines are available?
What about taking oral antihistamines during pregnancy or while breastfeeding?
Non-drug interventions should always be considered first in pregnant women suffering from symptoms of allergic rhinitis. Nondrug therapies include saline or salt-water nasal sprays, exercise, and nasal strips.
If a daily antihistamine is needed during pregnancy, second generation agents are preferred because they are less sedating and have a better side effect profile (have fewer anticholingeric side effects). Loratadine and cetirizine are preferred second generation antihistamines for pregnant women because they have the most safety and efficacy data. Both agents are rated FDA category B, and are generally considered to be safe at recommended doses for the treatment of allergic rhinitis during pregnancy. Fexofenadine is less well-studied and is rated FDA pregnancy category C.
First generation antihistamines are usually used on an as-needed basis or before bedtime to occasionally help with sleep. Chlorpheniramine is the preferred first generation antihistamine for people who are pregnant because it has been studied the most.
Medically Reviewed by a Doctor on 7/9/2015
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