What drugs interact with oral antihistamines?
Antihistamines may cause drowsiness. Taking antihistamines with other medicines that also are sedating may cause profound drowsiness. Examples include:
- Sleeping pills
- Seizure medications
- Some antidepressants (especially tricyclic antidepressants)
- Muscle relaxants
- Prescription narcotic pain medications
- Other antihistamines
- MAOIs (monoamine oxidase inhibitors), a class of medications used to treat mood disorders, may prolong or intensify the anticholinergic side effects of antihistamines. Generally, first generation antihistamines should not be used within two weeks of using a MAOI.
What formulations of oral antihistamines are available?
- Chewable tablets
- Orally disintegrating tablets
- In-combination with decongestants and pain relievers
What about taking oral antihistamines during pregnancy or while breastfeeding?
Non-drug interventions should always be considered first in pregnant women suffering from symptoms of allergic rhinitis. Nondrug therapies include saline or salt-water nasal sprays, exercise, and nasal strips.
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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