What are the side effects of oral antihistamines?
First generation antihistamines are used less often to treat allergies because they cause significant sedation. First generation antihistamines also should be used cautiously in older adults as they are more susceptible to their anticholingeric side effects including
- dry mouth,
- decreased tear production,
- urinary retention (trouble urinating),
- blurred vision,
- constipation, and
Due to their significant side effect profile, special precautions should be used in patients with:
- Problems passing urine or men with prostate problems
- Thyroid disorders
- High blood pressure
Second generation antihistamines are less sedating than their first generation counterparts. Cetirizine can be sedating for some patients at normal recommended doses while sedation seems to only be a concern with loratadine at higher than normally recommended doses. Fexofenadine is the least sedating.
Side effects common to all antihistamines include:
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