MAOIs are associated with several significant drug interactions; limiting their usefulness in patients who are treated with multiple drugs. MAOIs interact with drugs that increase serotonin activity in the brain, increase norepinephrine, constrict blood vessels, or inhibit monoamine oxidase.
Drugs that increase serotonin in the brain include:
- selective serotonin reuptake inhibitors, for example, fluoxetine (Prozac) and sertraline (Zoloft),
- serotonin norepinephrine reuptake inhibitors, for example, venlafaxine (Effexor) and desvenlafaxine (Pristiq),
- tricyclic antidepressants, for example, imipramine (Tofranil),
- St. John's Wort,
- tramadol (Ultram),
- propoxyphene (Darvon), and
- other MAOIs, for example, tranylcypromine (Parnate), phenelzine (Nardil).
Combining MAOIs with drugs that increase serotonin may cause:
Quick GuideDepression Hurts: Physical Symptoms of Depression
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Need help identifying pills and medications?
Use the pill identifier tool on RxList.