Antidepressants (Depression Medications) (cont.)

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Combining MAOIs with drugs that increase serotonin may cause:

Combining MAOIs with norepinephrine or drugs that constrict blood vessels (epinephrine, amphetamines, pseudoephedrine, ephedrine, phenylpropanolamine, and phenylephrine) may increase blood pressure to dangerous levels.

The antibiotic linezolid (Zyvox) and intravenous methylene blue should not be combined with MAOIs because they also inhibit monoamine oxidase.

MAOIs should be discontinued at least two weeks before administration of drugs that interact with MAOIs. Drugs that interact with MAOIs should be discontinued at least 1-2 weeks before administration of MAOIs. Because the effect of fluoxetine lasts for several weeks after discontinuation, MAOIs should not be initiated for at least five weeks after stopping fluoxetine.

What are tricyclic antidepressants (TCAs)?

TCAs have been in use since the 1950s when imipramine (Tofranil) was shown to be effective for treating depression. TCAs primarily work by increasing the level of norepinephrine in the brain and to a lesser extent serotonin levels. Some TCAs also are antihistamines (block the action of histamine) or anticholinergic (block the action of acetylcholine, a neurotransmitter), and these additional actions allow for uses of TCAs other than for treating depression as well as additional side effects.

What are examples of TCAs?

Medically Reviewed by a Doctor on 2/2/2015

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