Anticholinergic and Antispasmodic Drugs

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

Who should not use anticholinergic (antispasmodic) medications?

Patients with the following medical conditions should not use medications with anticholinergic properties since use of anticholinergic medications can worsen their conditions:

What drugs interact with anticholinergic (antispasmodic) drugs?

The use of multiple drugs with anticholinergic properties may be problematic because of their cumulative anticholinergic side effects. Examples of medications with anticholinergic properties that should not be combined include:

  • Antipsychotics
  • Certain antidepressants
  • Histamine 1-receptor blockers (H1RA)
  • Antispasmodics
  • Anti-diarrheal medications
  • Parkinson's medications
  • Overactive bladder (OAB) medications
  • Motion sickness medications
  • Certain antiemetics

Patients are advised to consult with their doctor or pharmacist for more information regarding potential drug interactions.

Medically Reviewed by a Doctor on 9/18/2015

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