Anticholinergic drugs decrease the activity of muscles in the gut and reduce production of sweat, saliva, digestive juices, urine, and tears. Additionally, anticholinergic drugs help to balance the production of dopamine, another neurotransmitter that plays an important role in maintaining mood, movement, memory, attention, problem solving, motivation, and pleasure.
In addition to drugs that are primarily anticholinergic, there are drugs used for purposes other than nerve, muscle, or glandular problems which have some anticholinergic effects that are considered side effects, for example, antipsychotic and antidepressant drugs.
What diseases and conditions do anticholinergic (antispasmodic) drugs treat?
- Overactive bladder
- Movement problems in Parkinson's disease
- Motion sickness
- Nausea and/or vomiting
- Muscle spasms
- Chronic obstructive pulmonary disease (COPD)
What are examples of prescription anticholinergic (antispasmodic) agents available in the US?
A variety of medications with anticholinergic properties are available for the treatment of various medical conditions.
Anticholinergic activity drugs
- Parkinson's medications
- diphenhydramine (Benadryl)
- trihexyphenidyl (Artane)
- benztropine mesylate (Cogentin)
- biperiden (Akineton)
- clomipramine (Anafranil)
- chlorpromazine (Thorazine)
- clozapine (Clozaril)
- fluphenazine (Prolixin)
- loxapine (Loxitane)
- olanzapine (Zyprexa)
- perphenazine (Trilafon)
- pimozide (Orap)
- quetiapine (Seroquel)
- thioridazine (Mellaril)
- thiothixene (Navane)
- trifluoperazine (Stelazine)
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