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Antibiotic Resistance
(Drug Resistance, Antimicrobial Resistance)

Antibiotics 101

Medical Author: Melissa Conrad Stöppler, MD
Medical Editor: William C. Shiel, Jr, MD, FACP, FACR

Antibiotic resistance is a growing healthcare problem, are you at risk?Mary thinks she may have a bladder infection. She makes the call to her doctor and is able get an appointment to come in and give a urine sample. Sure enough, bladder infection. Her doctor prescribes an antibiotic for the infection. Mary goes to the pharmacy, fills the prescription and as she is driving home, begins to think of questions that she should have asked her doctor about the antibiotic.

This scenario has run through many patients' minds. What are the side effects of the antibiotic? How soon should I begin to feel better? What if I don't feel better after 4 or 5 days? When should I call my doctor? Should I be concerned about a rash or other side effects that develop while taking the antibiotic?

Antibiotics 101

Antibiotics are a class of drugs that treat bacterial infections by stopping growth of bacteria or killing the bacteria directly. It's important to remember that antibiotics are ineffective in treating infections causes by viruses, which include the majority of colds, sore throats (with the exception of streptococcus-induced, or so-called "strep throat"), coughs, and flu-like illnesses.

Quick facts

  • Increasing use of antimicrobials in humans, animals, and agriculture has resulted in many microbes developing resistance to these powerful drugs.

  • Many infectious diseases are increasingly difficult to treat because of antimicrobial-resistant organisms, including HIV infection, staphylococcal infection, tuberculosis, influenza, gonorrhea, candida infection, and malaria.

  • Between 5 and 10 percent of all hospital patients develop an infection, leading to an increase of about $5 billion in annual U.S. healthcare costs.

  • About 90,000 of these patients die each year as a result of their infection, up from 13,300 patient deaths in 1992.

  • People infected with antimicrobial-resistant organisms are more likely to have longer hospital stays and may require more complicated treatment.

Definitions

Antimicrobial

Antimicrobial is a general term given to substances including medicines that kill or slow the growth of microbes.

Microbe is a collective name given to bacteria (Staphylococcus aureus), viruses (influenza, which causes the "flu"), fungi (e.g., Candida albicans, which causes some yeast infections), and parasites (e.g., Plasmodium falciparum, which causes malaria).

Examples of antimicrobial agents:



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Antibiotic Resistance (Drug Resistance, Antimicrobial Resistance)

When was HIV discovered, and how is it diagnosed?

In 1981, homosexual men with symptoms of a disease that now are considered typical of the acquired immunodeficiency syndrome (AIDS) were first described in Los Angeles and New York. The men had an unusual type of lung infection (pneumonia) called Pneumocystis carinii (now known as Pneumocystis jiroveci) pneumonia (PCP) and rare skin tumors called Kaposi's sarcomas. The patients were noted to have a severe reduction in a type of cell in the blood that is an important part of the immune system, called CD4 cells. These cells, often referred to as CD4 T cells, help the body fight infections. Shortly thereafter, this disease was recognized throughout the United States, Western Europe, and Africa. In 1983, researchers in the United States and France described the virus that causes AIDS, now known as the human immunodeficiency virus (HIV) and belonging to the group of viruses called re...

Read the Human Immunodeficiency Virus article »











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