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Special Precautions & Warnings:Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking annatto if you are pregnant or breast-feeding. Stay on the safe side and avoid use.
Diabetes: Annatto might increase or decrease blood sugar levels. Monitor your blood sugar carefully if you have diabetes and use annatto as a medicine. The dose of your diabetes medication may need to be changed.
Surgery: Annatto might affect blood sugar levels. This has raised some concern that it might interfere with blood sugar control during and after surgery. Stop using annatto as a medicine at least 2 weeks before a scheduled surgery.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.