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February 8, 2012

Anal Cancer

Treatment of Anal Cancer

Medical Author: Melissa Conrad Stöppler, MD
Medical Editor: William C. Shiel Jr., MD, FACP, FACR

Get information about treatments for anal cancer.The treatment of cancer of the anus is different than the treatment of cancers around the anus. True anal cancers arise from the lining cells of the anus, the last portion of the gastrointestinal tract after the rectum. Cancers that arise outside of the anus in the skin are termed perianal skin cancers or anal margin cancers. These are treated as skin cancers and not as true anal cancers.

Although anal cancer is rare (comprising only 1.8% of all malignancies of the digestive tract), its incidence is on the rise. While the exact cause of anal cancer hasn't been determined, researchers have shown that it is highly associated with human papillomavirus (HPV) infection. HPV is the virus that is known to cause cervical cancer in women.

As with any cancer, treatment is dependent upon the type, size, and extent of spread (stage) of the particular tumor as well as the overall health status of the patient. Surgery is no longer the standard treatment for most forms of anal cancer, although this option was used routinely in the past. Formerly, anal cancers were treated with a surgical procedure known as abdominoperineal resection (APR). The procedure required removal of the anorectum and the creation of a permanent colostomy, an opening made in the abdomen through which feces pass out of the body to be collected in a special bag attached to the body.

General Information About Anal Cancer

Anal cancer is a disease in which malignant (cancer) cells form in the tissues of the anus.

The anus is the end of the large intestine, below the rectum, through which stool (solid waste) leaves the body. The anus is formed partly from the outer skin layers of the body and partly from the intestine. Two ring-like muscles, called sphincter muscles, open and close the anal opening to let stool pass out of the body. The anal canal, the part of the anus between the rectum and the anal opening, is about 1½ inches long.

The skin around the outside of the anus is called the perianal area. Tumors in this area are skin tumors, not anal cancer.

Being infected with the human papillomavirus (HPV) can affect the risk of developing anal cancer.

Risk factors include the following:

  • Being over 50 years old.


  • Being infected with human papillomavirus (HPV).


  • Having many sexual partners.


  • Having receptive anal intercourse (anal sex).


  • Frequent anal redness, swelling, and soreness.


  • Having anal fistulas (abnormal openings).


  • Smoking cigarettes.
Picture of the anatomy of the lower digestive system, showing the colon and other organs.
Anatomy of the lower digestive system, showing the colon and other organs.



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Anal Cancer

What is flexible sigmoidoscopy?

Flexible sigmoidoscopy is a procedure that allows your doctor to examine the rectum and the lower (sigmoid) colon. The flexible sigmoidoscope is a flexible tube 60 cm long and about the thickness of your little finger. It is inserted gently into the anus and advanced slowly into the rectum and the lower colon. It is an accurate and simple method of investigating the cause of rectal bleeding, change in bowel habit, and rectal symptoms such as pain and diarrhea. Flexible sigmoidoscopy also is a part of colon screening and surveillance for colon cancer.

What is the preparation for flexible sigmoidoscopy?

In order to obtain accurate results, the rectum and the lower colon must be completely clean of stool. Your doctor will give you detailed instructions on how to cleanse your colon. In general, this requires the use of one or two enemas prior to the procedure and may also call for a laxative and some dietar...

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