anakinra, Kineret

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

Get a Grip on Rheumatoid Arthritis

Anakinra also is for used for treatment of neonatal-onset multisystem inflammatory disease (NOMID) due to cryopyrin-associated periodic syndromes (CAPS).

SIDE EFFECTS: The most common side effects are reactions at the site of injection, for example, redness, swelling and pain.

Other minor side effects include:

The most serious side effects are an increase in infections and a decrease in the number of white blood cells (neutropenia) and platelets.

Anakinra should not be started in individuals with active infections.

Infections occur more frequently when anakinra is used in combination with drugs that block tumor necrosis factor.

PRESCRIPTION: Yes

GENERIC AVAILABLE: No

PREPARATIONS: Pre-filled syringes, 100 mg

STORAGE: Anakinra should be kept refrigerated at 2 C to 8 C (36 F to 46 F)

DOSING:

  • The dose of anakinra for rheumatoid arthritis is one subcutaneous injection of 100 mg daily. The dose should be administered at approximately the same time every day.
  • The dose for treating neonatal-onset multisystem inflammatory disease (NOMID) is 1-2 mg/kg daily up to a maximum dose of 8 mg/kg.

DRUG INTERACTIONS: Anakinra should not be combined with drugs that block tumor necrosis factor (TNF) alpha. Combining anakinra with drugs that block tumor necrosis factor such as infliximab (Enbrel) and etanercept (Remicade) or other drugs that reduce function of the immune system increases the risk of serious infections.

PREGNANCY: Anakinra has not been studied in pregnant women.

NURSING MOTHERS: It is not known if anakinra is excreted in the breast milk of females who are nursing.

Reference: FDA Prescribing Information

Medically Reviewed by a Doctor on 12/15/2014

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