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amprenavir - oral, Agenerase (cont.)

PRECAUTIONS: Before taking amprenavir, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart problems (coronary disease, heart attack), liver problems (e.g., hepatitis B, hepatitis C), alcohol use, diabetes, hemophilia, lipid problems (high cholesterol or triglycerides/fats).If you have diabetes, this product may increase your blood sugar levels. Check your blood sugar levels regularly as directed by your doctor. Tell your doctor immediately if you have symptoms of high blood sugar, such as increased thirst and urination. Your anti-diabetic medication or diet may need to be adjusted.This medication should be used only when clearly needed during pregnancy. However, it is now normal to prescribe HIV medicines for pregnant women with HIV. This has been shown to decrease the risk of giving HIV to the baby. Amprenavir may be part of that treatment. Discuss the risks and benefits with your doctor.It is not known if this medication passes into breast milk. Because breast milk can transmit HIV, do not breast-feed.

DRUG INTERACTIONS: See also How to Use section.Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop or change the dosage of any medicine before checking with them first.This drug should not be used with the following medications because very serious interactions may occur: amiodarone, bepridil, delavirdine, etravirine, quinidine, tricyclic antidepressants (e.g., amitriptyline, desipramine, imipramine), cisapride, pimozide, dihydroergotamine, ergonovine, ergotamine, methylergonovine, St John's wort, midazolam, triazolam, simvastatin, lovastatin, rifampin, ranolazine, artemether/lumefantrine.Avoid using hormonal birth control (e.g., pills, patch, ring) while taking this medication. Using hormonal birth control while also taking this medication can make both drugs less effective. Consult your doctor or pharmacist for more details and for information about other birth control methods. To reduce the risk of spreading HIV to others, always use effective barrier protection during all sexual activity. (See also Notes section.)If amprenavir is taken with ritonavir, the following medications should also not be used: flecainide, propafenone.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: garlic capsules, sildenafil, tadalafil, vardenafil, trazodone, ketoconazole, itraconazole, saquinavir, lopinavir/ritonavir, indinavir, nelfinavir, didanosine (dispersible tablets/solution), nevirapine, efavirenz, carbamazepine, phenobarbital, phenytoin, rifabutin, fluticasone, atorvastatin, certain calcium channel blockers (e.g., nifedipine, felodipine, nicardipine), warfarin, ranitidine, dexamethasone, certain drugs that weaken the immune system (cyclosporine, tacrolimus, sirolimus), temsirolimus, alprazolam, diazepam, flurazepam, clonazepam, clorazepate, estazolam, methadone.If any of these medications are taken with amprenavir, your doctor may change your dose of amprenavir or the other drug(s), or your doctor may monitor you specially. Consult your doctor or pharmacist for more details.This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.



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