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- What is amprenavir, and how does it work (mechanism of action)?
- What brand names are available for amprenavir?
- Is amprenavir available as a generic drug?
- Do I need a prescription for amprenavir?
- What are the side effects of amprenavir?
- What is the dosage for amprenavir?
- Is amprenavir safe to take if I'm pregnant or breastfeeding?
- What else should I know about amprenavir?
What is amprenavir, and how does it work (mechanism of action)?
Amprenavir is an oral medication that is used for treating infections with the human immunodeficiency virus (HIV). It is in a class of drugs called protease inhibitors which, among others, includes indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir) and saquinavir (Invirase, Fortovase). During infection with HIV, the HIV virus multiplies within the body's cells. Viruses are released from the cells and spread throughout the body where they infect other cells. In this manner, HIV infection is perpetuated among new cells that the body produces continually. During the production of the viruses, new proteins are made. Some of the proteins are structural proteins, that, is, proteins that form the body of the virus. Other proteins are enzymes which manufacture DNA and other components for the new viruses. Protease is the enzyme that forms the new structural proteins and enzymes. Amprenavir blocks the activity of protease and results in the formation of defective viruses that are unable to infect the body's cells. As a result, the number of viruses in the body (the viral load) decreases. Nevertheless, amprenavir does not prevent the transmission of HIV among individuals, and it does not cure HIV infections or AIDS. Amprenavir was approved by the FDA in April 1999.
What brand names are available for amprenavir?
Agenerase (Discontinued Brand)
Is amprenavir available as a generic drug?
GENERIC AVAILABLE: No
Do I need a prescription for amprenavir?
What are the side effects of amprenavir?
The most frequent side effects are headache, weakness, diarrhea, nausea and stomach pain. Amprenavir may also cause severe skin reactions and breakdown of red blood cells. The propylene glycol in the oral solution can cause seizures, stupor, increased heart rate, metabolic disturbance, and kidney failure. Like other protease inhibitors, use of amprenavir may be associated with redistribution or accumulation of body fat, increased cholesterol and worsening of diabetes.
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