amphetamine and dextroamphetamine, Adderall, Adderall XR (cont.)

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Medical and Pharmacy Editor:

DRUG INTERACTIONS: Amphetamines should not be taken with monoamine oxidase (MAO) inhibitor drugs including phenelzine (Nardil), tranylcypromine (Parnate), and Zyvox; use of amphetamine within 14 days of using MAO inhibitor drugs should be avoided. Patients receiving antihypertensive medications may experience loss of blood pressure control with amphetamine. Antacids may increase absorption of amphetamine salts and increase their effectiveness and side effects.

PREGNANCY: Amphetamines should not be used during pregnancy. Infants who are born to mothers dependent on amphetamines exhibit symptoms of withdrawal and have an increased risk of low birth weight.

NURSING MOTHERS: Mothers taking amphetamines should refrain from nursing their infants because these drugs are excreted in human milk and can have undesirable effects on the child.

SIDE EFFECTS: Side effects of amphetamines include excessive stimulation of the nervous system leading to nervousness, restlessness, excitability, dizziness, headache, insomnia, fear, anxiety, tremor, and even hallucinations and convulsions (seizures). Blood pressure and heart rate may increase, and patients may experience palpitations of the heart. Sudden death, stroke, heart attack, depression, manic episodes, aggressive behavior or hostility, psychosis, growth suppression (long-term use), dependence, and withdrawal symptoms may also occur.

Priapism defined as painful and nonpainful penile erection lasting more than 4 hours, have been reported in pediatric and adult patients treated with stimulants. The erection usually resolves when the drug is stopped. Prompt medical attention is required in the event of suspected priapism.

Reference: FDA Prescribing Information


Medically Reviewed by a Doctor on 2/4/2014


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