amoxicillin and clavulanic acid, Augmentin, Augmentin XR
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
GENERIC NAME: amoxicillin and clavulanic acid
BRAND NAME: Augmentin, Augmentin XR
DRUG CLASS AND MECHANISM: Augmentin contains amoxicillin and clavulanic acid. Amoxicillin is an antibiotic of the penicillin type. It is effective against some bacteria such as H. influenzae, N. gonorrhea, E. coli, Pneumococci, Streptococci, and certain strains of Staphylococci. Chemically, it is closely related to penicillin and ampicillin. Amoxicillin stops bacteria from multiplying by preventing bacteria from forming the walls that surround them. The walls are necessary to protect bacteria from their environment and to keep the contents of the bacterial cell together. Bacteria cannot survive without a cell wall. Clavulanic acid enhances the effectiveness of amoxicillin against bacteria that are ordinarily resistant to amoxicillin alone.
GENERIC AVAILABLE: Yes
STORAGE: Tablets and dry powder should be stored at room temperature below 25 C (77 F), the former in a tightly closed container. Diluted powder should be refrigerated and discarded after 10 days.
PRESCRIBED FOR: Augmentin is effective against susceptible bacteria causing infections of the middle ear (otitis media), tonsillitis, throat infections (pharyngitis), laryngitis, bronchitis, sinusitis, and pneumonia. It is also used in treating urinary tract infections, and skin infections.
DOSING: Augmentin should be taken on a full stomach to reduce stomach upset. No more than one tablet should be taken at a time since the extra clavulanic acid can cause stomach upset. Recommended adult doses are 500 mg every 8-12 hours, 250 mg every 8 hours, 875 mg every 12 hours, or 2000 mg every 12 hours. Dosing is based on the amoxicillin component. Pediatric patients weighing more than 40 kg should receive adult doses. Pediatric patients weighing less than 40 kg should receive 20 to 45 mg/kg every 8 or 12 hours.
DRUG INTERACTIONS: Co-administration of probenecid, a drug used for treating gout, prevents the normal elimination of amoxicillin by the kidneys and can cause high, toxic blood levels of amoxicillin. Augmentin may decrease the effectiveness of birth control pills, increasing the risk of unexpected pregnancies. Combining Augmentin and allopurinol (Zyloprim, Aloprim) may increase the occurrence of skin rash.
PREGNANCY: Use of Augmentin in pregnant women has not been well studied. Penicillins are generally considered safe for use by pregnant women who are not allergic to penicillin.
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