DRUG INTERACTIONS: See also the How to Use section. This drug should not be used with the following medications because very serious (possibly fatal) interactions may occur: certain azole antifungals (e.g., itraconazole, ketoconazole), certain macrolide antibiotics (e.g., clarithromycin, erythromycin, troleandomycin), mibefradil, nefazodone, telithromycin. If you are currently using any of these medications, tell your doctor or pharmacist before starting amlodipine/atorvastatin. Use caution if the following drugs are combined with atorvastatin because serious side effects such as muscle injury (myopathy) infrequently could occur: fibrates (e.g., gemfibrozil, fenofibrate), high-dose niacin (1 gram or more per day). Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: birth control pills, intravenous (IV) calcium, other medications for chest pain (e.g., nitroglycerin), clopidogrel, digoxin, other high blood pressure medications (e.g., beta-blockers, "water pills"/diuretics), HIV protease inhibitors (e.g., indinavir, ritonavir), other drugs which affect certain liver enzymes (CYP 3A4 substrates, inhibitors, and inducers such as amiodarone, cyclosporine, diltiazem, verapamil, rifampin, St. John's wort, carbamazepine). Check the labels on all your medicines (e.g., cough-and-cold products, diet aids) because they may contain ingredients that could increase your heart rate or blood pressure. Ask your pharmacist about the safe use of those products. Do not start or stop any medicine without doctor or pharmacist approval.

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