amlodipine and benazepril, Lotrel (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Nitritoid reactions (symptoms include facial flushing, nausea, vomiting and low blood pressure or hypotension) may occur when injectable gold (sodium aurothiomalate), used in the treatment of rheumatoid arthritis, is combined with ACE inhibitors.

Amlodipine increases blood levels of simvastatin (Zocor). The dose of simvastatin should be limited to 20 mg daily when combined with amlodipine.

PREGNANCY: ACE inhibitors, including benazepril, can be harmful to the fetus and should not be taken by pregnant women.

NURSING MOTHERS: Small amounts of benazepril are excreted in breast milk. It is not known whether amlodipine is excreted in breast milk. Lotrel or nursing should be discontinued.

SIDE EFFECTS: Lotrel causes the same side effects as benazepril and amlodipine. Common side of Lotrel include water retention (edema) in legs and arms, stomach pain, nausea, dizziness, fatigue, headache, muscle cramps, sexual problems, and drowsiness. Overgrowth of gums, heart palpitations, anemia, reduced number of platelets, and serious skin reactions also may occur.

Reference: FDA Prescribing Information

Last Editorial Review: 4/3/2012

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